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Inhibition of MMP-14 (unknown origin) using 5-FAM-TDVPNGFHVS (QXL520)-NH2 as fluorogenic substrate at 12.5 to 200 uM preincubated for 10 mins followed by substrate addition and measured for 50 mins by microplate reader assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Binding affinity to CMS sensor chip immobilized MMP-14 catalytic domain (unknown origin) assessed as equilibrium dissociation constant by surface plasmon resonance analysis
Assay data:2 Active, 2 Tested
Inhibition of MMP-14 (unknown origin) using 5-FAM-TDVPNGFHVS (QXL520)-NH2 as fluorogenic substrate preincubated for 10 mins followed by substrate addition and measured for 50 mins by microplate reader assay
Assay data:3 Tested
Inhibition of MMP-14 (unknown origin) using 5-FAM-TDVPNGFHVS (QXL520)-NH2 as fluorogenic substrate at 47.6 uM preincubated for 10 mins followed by substrate addition by primary HTS analysis relative to control
Assay data:1 Active, 3 Tested
Inhibition of MMP14 (unknown origin)
Inhibition of MMP14 (unknown origin) assessed as inhibition constant
Assay data:7 Active, 6 Activity ≤ 1 µM, 7 Tested
Inhibition of MMP14 (unknown origin) by FRET assay
Inhibition of MMP-14 (unknown origin) at 20 uM by fluorometric assay
Inhibition of MMP-14 (unknown origin)
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
Inhibition of human recombinant MMP14 catalytic domain using Mca-Lys-Pro-Leu-Gly-Leu-Dap(Dnp)-Ala-Arg-NH2 as substrate preincubated with enzyme for 3 hrs followed by substrate addition and measured every 10 secs for 15 mins by fluorescence based analysis
Assay data:4 Tested
Inhibition of MMP-14 (unknown origin) using fTHP-15(FAM) as substrate at 10 uM
Assay data:9 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of MMP-14 (unknown origin) using fTHP-15(FAM) as substrate at 5 uM
Assay data:5 Tested
Selectivity interaction (MMPs panel (FRET assay)) EUB0000730a MMP14
Assay data:1 Active, 1 Tested
Selectivity interaction (MMPs panel (enzymatic assay)) EUB0000729a MMP14
Selectivity interaction (Lead profiling screen (Eurofins, enzymes, transporters, GPCRs, ion chanels)) EUB0000728a MMP14
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (MMPs panel (Panlabs panel, Bayer)) EUB0000725a MMP14
Inhibition of recombinant human MMP14 using MOCAc-Lys-Pro-Leu-Gly-Leu-A2pr(Dnp)-Ala-Arg-NH2 as substrate preincubated for 15 mins followed by substrate addition by fluroscence based assay
Assay data:5 Active, 3 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of human MMP-14 using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 1 hr followed by susbstrate addition by fluorescent analysis
Inhibition of human MMP-14 expressed in Escherichia coli BL21(DE3) using Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 as substrate preincubated for 30 mins followed by susbstrate addition by photon-counter spectrophotometer analysis
Assay data:3 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of MMP-14 (unknown origin) expressed in Escherichia coli BL21(DE3) and measured for 2 mins by enzymatic assay
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
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