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Binding affinity to human recombinant BMP2 by surface plasmon resonance assay
Assay data:3 Tested
SummaryPubMed CitationRelated BioAssays by Target
Binding affinity to human recombinant BMP4 by surface plasmon resonance assay
Binding affinity to human BMP-2 (amino acid residues M1 to R115) at 0.125 to 2 uM by surface plasmon resonance assay
Assay data:1 Tested
SummaryRelated BioAssays by Target
Inhibition of BMP4 in mouse C2C12BRA cells after 14 hrs by luciferase reporter gene assay
Assay data:15 Active, 3 Activity ≤ 1 nM, 12 Activity ≤ 1 µM, 32 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Developing potent and selective BMP inhibitors as translational tools to develop future therapies
SummaryRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Discovery and structure-activity relationship of BMP Inhibitors
Assay data:16 Active, 11 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Increase in BMP2-mediated osteoblastogenesis assessed as increase in Kv4.3 mRNA expression at 10 uM after 6 hrs after 3 days by RT-PCR analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Increase in BMP2-mediated osteoblastogenesis assessed as increase in Kv4.2 mRNA expression at 10 uM after 6 hrs after 3 days by RT-PCR analysis
Increase in BMP2-mediated osteoblastogenesis assessed as increase in Kv1.5 mRNA expression at 10 uM after 3 days by RT-PCR analysis
Increase in BMP2-mediated osteoblastogenesis assessed as increase in Kv1.1 mRNA expression at 10 uM by RT-PCR analysis
Increase in BMP2-mediated osteoblastogenesis assessed as increase in phosphorylated of Smad level in nucleus at 10 uM after 6 hrs by Western blot analysis
Increase in BMP2-mediated osteoblastogenesis assessed as increase in phosphorylation of Smad at 10 uM by Western blot analysis
Increase in BMP2-mediated osteoblastogenesis assessed as increase in nuclear translocation of Smad at 10 uM by Western blot analysis
Increase in human recombinant BMP2-mediated osteoblastogenesis assessed as increase in alkaline phosphatase activity in mouse C2C12 cells at 10 uM treated with BMP2 antagonist on day 4 post compound challenge measured after 6 days
Increase in human recombinant BMP2-mediated osteoblastogenesis assessed as increase in alkaline phosphatase mRNA expression in mouse C2C12 cells at 10 uM treated with BMP2 antagonist noggin on day 4 post compound challenge measured after 6 days by SYBR-based RT-PCR
Increase in human recombinant BMP2-mediated osteoblastogenesis assessed as increase in alkaline phosphatase activity in mouse C2C12 at 10 uM co-treated with BMP2 antagonist noggin on day 3 measured after 6 days
Increase in human recombinant BMP2-mediated osteoblastogenesis assessed as increase in alkaline phosphatase mRNA expression in mouse C2C12 at 10 uM co-treated with BMP2 antagonist noggin on day 3 measured after 6 days by SYBR-based RT-PCR
Increase in BMP2-mediated osteoblastogenesis assessed as increase in BMP7 protein level in mouse C2C12 cells at 10 uM by Western blot analysis
Increase in BMP2-mediated osteoblastogenesis assessed as increase in BMP2 protein level in mouse C2C12 cells at 10 uM by Western blot analysis
Increase in BMP2-mediated osteoblastogenesis in mouse C2C12 cells assessed as increase in OCN mRNA level at 10 uM by SYBR-based RT-PCR
Assay data:4 Active, 4 Tested
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