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Inhibition Assay from Article 10.1111/cbdd.12241: "Synthesis and evaluation of novel oleanolic acid derivatives as potential antidiabetic agents."
Assay data:3 Active, 17 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition Activity Assay from Article 10.1016/S1074-5521(00)00004-1: "Human liver glycogen phosphorylase inhibitors bind at a new allosteric site."
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Glycogen Phosphorylase Activity Assay from Article 10.1016/j.bmc.2008.04.010: "Synthesis of 5-chloro-N-aryl-1H-indole-2-carboxamide derivatives as inhibitors of human liver glycogen phosphorylase a."
Assay data:21 Active, 6 Activity ≤ 1 µM, 25 Tested
Glycogen Phosphorylase Activity Assay from Article 10.1016/j.bmc.2008.10.021: "Design, synthesis, and pharmacological evaluation of N-bicyclo-5-chloro-1H-indole-2-carboxamide derivatives as potent glycogen phosphorylase inhibitors."
Assay data:15 Active, 13 Activity ≤ 1 µM, 16 Tested
GPa Inhibition Assay from Article 10.1016/j.bmc.2009.04.049: "Glycogen phosphorylase inhibitory effects of 2-oxo-1,2-dihydropyridin-3-yl amide derivatives."
Assay data:1 Active, 9 Tested
Enzyme Inhibition Assay from Article 10.1016/j.bmc.2009.08.060: "Glucose-based spiro-isoxazolines: a new family of potent glycogen phosphorylase inhibitors."
Assay data:3 Active, 1 Activity ≤ 1 µM, 5 Tested
Glycogen Phosphorylase Enzyme Assay from Article 10.1016/j.bmc.2009.08.045: "Benzamide derivatives as dual-action hypoglycemic agents that inhibit glycogen phosphorylase and activate glucokinase."
Assay data:11 Active, 1 Activity ≤ 1 µM, 32 Tested
Human Liver GPa Enzymatic Activity Assay from Article 10.1016/j.bmcl.2008.12.085: "Anthranilimide based glycogen phosphorylase inhibitors for the treatment of type 2 diabetes. Part 3: X-ray crystallographic characterization, core and urea optimization and in vivo efficacy."
Assay data:23 Active, 22 Activity ≤ 1 µM, 23 Tested
Enzyme Inhibition Assay from Article 10.1016/j.bmcl.2006.10.037: "Development of potent, orally active 1-substituted-3,4-dihydro-2-quinolone glycogen phosphorylase inhibitors."
Assay data:38 Active, 38 Activity ≤ 1 µM, 38 Tested
Enzyme Inhibition Assay from Article 10.1021/jm8000949: "Naturally Occurring Pentacyclic Triterpenes as Inhibitors of Glycogen Phosphorylase: Synthesis, Structure-Activity Relationships, and X-ray Crystallographic Studies."
Assay data:1 Active, 23 Tested
Activation of mouse liver Glycogen phosphorylase
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of GP in human HepG2 cells assessed as reduction in GP activity at 500 uM incubated for 3 hrs by Bradford reagent based assay relative to control
Assay data:2 Tested
Inhibition of GP in human HepG2 cells assessed as reduction in GP activity at 335 uM incubated for 3 hrs by Bradford reagent based assay relative to control
Inhibition of GP in human HepG2 cells assessed as reduction in GP activity at 100 uM incubated for 3 hrs by Bradford reagent based assay relative to control
Inhibition of human liver GPa using Glc-1-P as substrate incubated for 15 mins
Assay data:3 Active, 1 Activity ≤ 1 µM, 9 Tested
Binding affinity to PYGB in human NCI-H358 cells at 1 uM by mass spectrometry based pull down assay
Assay data:1 Active, 1 Tested
Competitive inhibition of rabbit muscle glycogen phosphorylase-b at 650 uM in presence of varying levels of glucose-1-phosphate and constant concentration of glycogen and AMP preincubated for 15 mins with AMP and glycogen followed by glucose-1-phosphate addition by Lineweaver-Burk plot method
Competitive inhibition of rabbit muscle glycogen phosphorylase-a in presence of varying levels of glucose-1-phosphate and constant concentration of glycogen and AMP preincubated for 15 mins with AMP and glycogen followed by glucose-1-phosphate addition by Lineweaver-Burk plot method
Assay data:3 Active, 1 Activity ≤ 1 µM, 4 Tested
Competitive inhibition of rabbit muscle glycogen phosphorylase-b in presence of varying levels of glucose-1-phosphate and constant concentration of glycogen and AMP preincubated for 15 mins with AMP and glycogen followed by glucose-1-phosphate addition by Lineweaver-Burk plot method
Assay data:3 Active, 1 Activity ≤ 1 µM, 6 Tested
Competitive inhibition of 6xHis-tagged human liver glycogen phosphorylase-a expressed in Escherichia coli BL21 Gold (DE3) assessed as release of inorganic phosphate using varying levels of glucose-1-phosphate and constant concentration of AMP and glycogen preincubated for 15 mins with AMP and glycogen followed by glucose-1-phosphate addition by Lineweaver-Burk plot method
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