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VEGFR ADP GLO Assay from US Patent US20240109917: "PYRAZOLOTHIAZOLE CARBOXAMIDES AND THEIR USES AS PDGFR INHIBITORS"
Assay data:23 Active, 13 Activity ≤ 1 µM, 485 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Mobility-Shift Assay from US Patent US11912663: "Multi-targeted tyrosine kinase inhibitors and their pharmaceutical uses"
Assay data:14 Active, 15 Activity ≤ 1 µM, 15 Tested
In Vitro Kinase Binding Assay from US Patent US20240058459: "DENDRIMER COMPOSITIONS AND METHODS FOR DRUG DELIVERY TO THE EYE"
Assay data:3 Active, 2 Activity ≤ 1 nM, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Safety47 Scan (DiscoverX - Eurofins)
Assay data:1 Tested
SummaryRelated BioAssays by Target
KDR Invitrogen Lab (UK) kinase screen (BI)
AMPK A1B1G1 Invitrogen Lab (UK) kinase screen (BI)
Compound was evaluated for inhibition of human KDR in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:12 Active, 3 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 101 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Assay data:19 Active, 11 Activity ≤ 1 µM, 692 Tested
Inhibition of VEGFR2 (unknown origin) at 10 uM by biochemical hotspot kinase assay
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of ALK5 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of VEGFR-2 (unknown origin) kinase activity using poly(Glu-Tyr) at 4:1 ratio as substrate in presence of ATP incubated for 60 mins by ELISA
Inhibition of VEGFR-2 (unknown origin)
Assay data:9 Active, 8 Activity ≤ 1 µM, 10 Tested
Inhibition of TGFBR1 (unknown origin) at 1 uM relative to control
Assay data:3 Tested
Inhibition of His-tagged human recombinant VEGFR2 (789 to 1356 residues) expressed in insect cells at 200 nM by Z'-lyte assay
Activation of AMPK phosphorylation in rat INS-1E beta-cells at 2 uM incubated for 24 hrs
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of AMPK phosphorylation in rat INS-1E cells incubated for 24 hrs
Activation of AMPK phosphorylation at Thr172 residue in rat L6 cells assessed as fold increase at 5 uM incubated for 24 hrs by Western blot analysis (Rvb = 0.6 No_unit)
Activation of AMPK phosphorylation at Thr172 residue in rat L6 cells assessed as fold increase at 2.5 uM incubated for 24 hrs by Western blot analysis (Rvb = 0.6 No_unit)
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