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AlphaScreen Assay from US Patent US9266891: "Substituted [1,2,4]triazolo[4,3-A]pyrazines that are BRD4 inhibitors"
Assay data:61 Active, 1 Activity ≤ 1 nM, 61 Activity ≤ 1 µM, 61 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Time Resolved Fluorescence Resonance Energy Transfer (TR-FRET) Assay from US Patent US9125915: "Antitumor agent"
Assay data:17 Active, 17 Activity ≤ 1 µM, 17 Tested
Activation of histone H4 acetylation in human K562 cells at 6.7 to 100 uM after 24 hrs by Western blot analysis
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Binding affinity to fluorescein-labeled Histone H4(1-20) assessed as peptide fluorescence quenching by spectrofluorometry
Assay data:1 Active, 1 Tested
Binding affinity to fluorescein-labeled Histone H4(1-20) by spectrofluorometry
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Acetylation of histone H4 at 0.3 uM by Western blot analysis
Acetylation of histone H4 at 5 uM by Western blot analysis
Acetylation of histone H4 at 2.5 uM by Western blot analysis
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