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Inhibition of human SR-B1 transiently expressed in human U2OS cells assessed as Dil-HDL uptake preincubated for 2 hrs followed by Dil-HDL addition measured after 2 hrs by FLIPR assay
Assay data:15 Active, 14 Activity ≤ 1 µM, 16 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as increase in binding of Alexa-488-labeled HDL particles to cells
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in uptake of [3H]CE from [3H]CE-HDL by by liquid scintillation counting method
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into cells pre-incubated for 2 hrs washed extensively with PBS and then incubated with DiI-HDL by fluorescence assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Reversible inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into cells by fluorescence assay
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of mouse SR-BI isoform 1 expressed in CHO cells assessed as reduction in transfer of fluorescent lipid DiI from human HDL particles into cells by fluorescence assay
Assay data:27 Active, 20 Activity ≤ 1 µM, 34 Tested
Inhibition of mouse SR-B1 overexpressed in CHO cells assessed as inhibition of receptor-mediated Alexa-594-labeled transferrin endocytosis up to 35 uM
Inhibition of mouse SR-B1 overexpressed in CHO cells assessed as inhibition of binding of ALexa-488-labeled HDL particles to cells after 3 hrs
Inhibition of mouse SR-B1 overexpressed in CHO cells assessed as inhibition of [3H]cholesteryl ester uptake into cells after 2 to 3 hrs by liquid scintillation counting
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Inhibition of mouse SR-B1 overexpressed in CHO cells assessed as inhibition of transfer of the fluorescent lipid DiI from HDL particles to cells at 1 uM after 3 hrs
Inhibition of mouse SR-B1 overexpressed in CHO cells assessed as inhibition of transfer of the fluorescent lipid DiI from HDL particles to cells after 3 hrs
Assay data:35 Active, 16 Activity ≤ 1 µM, 50 Tested
Inhibition of human SRB1-mediated Hepatitis C virus genotype 2a entry into human HuH7.5 cells by luciferase reporter gene assay
Assay data:34 Active, 34 Activity ≤ 1 µM, 34 Tested
Inhibition of human SRB1-mediated Hepatitis C virus genotype 1a entry into human HuH7.5 cells by immunoblotting
Inhibition of human SRB1-mediated Hepatitis C virus genotype 2a entry into human 293T cells by immunoblotting
Assay data:8 Active, 3 Activity ≤ 1 µM, 9 Tested
HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Inhibitor_Dose_DryPowder_Activity_Set10
Assay data:25 Active, 16 Activity ≤ 1 µM, 38 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
HDL Counter Assay: 3/24 Cytotox Measured in Cell-Based System Using Plate Reader - 2085-02_Inhibitor_Dose_DryPowder_Activity_Set6
Assay data:16 Active, 107 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Inhibitor_Dose_DryPowder_Activity_Set9
Assay data:19 Active, 14 Activity ≤ 1 µM, 22 Tested
HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Inhibitor_Dose_DryPowder_Activity_Set8
Assay data:64 Active, 23 Activity ≤ 1 µM, 92 Tested
HTS using DiI-HDL to assay lipid transfer in ldlA[SR-BI] cells Measured in Cell-Based System Using Plate Reader - 2085-01_Activator_Dose_CherryPick_Activity
Assay data:6 Active, 475 Tested
Liposome Uptake Assay Measured in Biochemical System Using Scintillation - 2085-16_Inhibitor_Dose_DryPowder_Activity
Assay data:3 Active, 4 Tested
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