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Affinity On-target Cellular interaction (Cellular activity assay (measurement of ATP levels in presence of complex II substrate succinate in H1299 cells)) EUB0000752a NDUFS2
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Affinity On-target Cellular interaction (Cellular activity assay (measurement of ATP levels in presence of complex II substrate succinate in H1299 cells)) EUB0000748a NDUFS2
Assay data:1 Tested
SummaryRelated BioAssays by Target
Affinity Phenotypic Cellular interaction (Proliferation assay (CellTiter-Glo ATP assay in human lung H1299 cells)) EUB0000752a NDUFS2
Inhibition Assay from US Patent US8952025: "Multifunctional radical quenchers and their uses"
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition Assay from Article 10.1021/bi8010362: "Synthesis and characterization of new piperazine-type inhibitors for mitochondrial NADH-ubiquinone oxidoreductase (complex I)."
Assay data:19 Active, 1 Activity ≤ 1 nM, 16 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Submitochondrial Particle Assay from US Patent US9713651: "Compositions, methods, and systems for the synthesis and use of imaging agents"
Assay data:38 Active, 53 Activity ≤ 1 µM, 55 Tested
Proliferation assay with cellular ATP kit HTS
Proliferation assay with CellTiter-Glo ATP
Kinobeads (epsilon), multiple immobilized ATP-competitive broad spectrum kinase inhibitors, used to assess residual binding of ~300 proteins simultaneously from cell lysate in the presence of a compound. Quantitative readout performed by mass spectrometry.
Assay data:1 Active, 228 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of Bos taurus (bovine) heart submitochondrial NADH complex 1 by NADH oxidase assay
Assay data:7 Tested
Inhibition of Bos taurus (bovine) heart submitochondrial particle NDH1 assessed as NADH-DB reductase activity
Assay data:32 Active, 8 Activity ≤ 1 µM, 54 Tested
Inhibition of Bos taurus (beef) heart NAD1 assessed as NADH oxidase activity
Assay data:7 Active, 2 Activity ≤ 1 µM, 13 Tested
Inhibition of Bos taurus (beef) heart NAD1 assessed as NADH-ubiquinone oxidoreductase activity
Assay data:3 Active, 9 Tested
Inhibition of Bos taurus (beef) heart NAD1
Inhibition of Bos taurus (bovine) mitochondrial complex 1 assessed as reduction in enzyme activity by NADH-HU oxidoreductase assay
Assay data:9 Active, 7 Activity ≤ 1 µM, 10 Tested
Inhibition of Bos taurus (bovine) mitochondrial complex 1 assessed as reduction in enzyme activity by NADH-DU oxidoreductase assay
Assay data:8 Active, 6 Activity ≤ 1 µM, 8 Tested
Inhibition of Bos taurus (bovine) mitochondrial complex 2 electron transfer activity
Assay data:7 Active, 4 Activity ≤ 1 µM, 8 Tested
Inhibition of Bos taurus (bovine) mitochondrial complex 2 electron transfer activity measured per mg of protein
Assay data:9 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of Bos taurus (bovine) mitochondrial complex 3 electron transfer activity
Assay data:6 Active, 6 Tested
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