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Bioluminescence Resonance Energy Transfer (BRET) Assay from US Patent US20240132519: "NRF2-ACTIVATING COMPOUND"
Assay data:35 Active, 24 Activity ≤ 1 nM, 35 Activity ≤ 1 µM, 35 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Invivo inhibition of Nrf2-Keap1 Kelch domain protein-protein interaction in po dosed Wistar rat kidney assessed as increase in HO-1 protein level by measuring fold change at 30 mg/kg incubated for 6 hrs by ELISA assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Invivo inhibition of Nrf2-Keap1 Kelch domain protein-protein interaction in po dosed Wistar rat kidney assessed as increase in HO-1 protein level incubated for 6 hrs by ELISA assay
Inhibition of Nrf2-Keap1 Kelch domain (unknown origin) protein-protein interaction in presence of biotin labeled 16mer ETGE peptide AFFAQLQLDEETGEFL
Assay data:5 Active, 2 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activation of Nrf2 in human IMR-32-ARE-Luc cells assessed as maximal efficacy by measuring fold change by Bright-Glo luciferase assay
Assay data:16 Tested
Activation of Nrf2 in human IMR-32-ARE-Luc cells by Bright-Glo luciferase assay
Assay data:13 Active, 5 Activity ≤ 1 µM, 16 Tested
Induction of Nrf2 nuclear translocation in rat PC12 cells measured for 12 hrs by FITC staining based confocal microscopic analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of Nrf2 pathway in rat PC-12 cells assessed as increase in Nrf2 accumulation in nucleus at 20 uM measured after 1 to 5 hrs by Western blot analysis
Activation of Nrf2 pathway in rat PC-12 cells assessed as decrease in Nrf2 accumulation in cytoplasm at 20 uM measured after 1 to 5 hrs by Western blot analysis
Activation of Nrf2 pathway in rat PC-12 cells assessed as fold increase in GCLM expression level at 1 to 20 uM measured at 6 hrs by qRT-PCR analysis
Activation of Nrf2 pathway in rat PC-12 cells assessed as fold increase in NQO1 expression level at 1 to 20 uM measured at 6 hrs by qRT-PCR analysis
Activation of Nrf2 pathway in rat PC-12 cells assessed as fold increase in HO-1 expression level at 1 to 20 uM measured at 6 hrs by qRT-PCR analysis
Activation of Nrf2 pathway in rat PC-12 cells assessed as fold increase in Nrf2 expression level at 1 to 20 uM measured at 6 hrs by qRT-PCR analysis
Activation of Nrf2 pathway in rat PC-12 cells assessed as fold increase in GCLM level at 20 uM measured at 2 hrs by qRT-PCR analysis
Activation of Nrf2 pathway in rat PC-12 cells assessed as fold increase in NQO1 level at 20 uM measured at 2 hrs by qRT-PCR analysis
Activation of Nrf2 pathway in rat PC-12 cells assessed as fold increase in HO-1 level at 20 uM measured at 2 hrs by qRT-PCR analysis
Activation of Nrf2 pathway in rat PC-12 cells assessed as fold increase in Nrf2 level at 20 uM measured at 2 hrs by qRT-PCR analysis
Induction of Nrf2 pathway in rat PC12 cells assessed as fold increase in Nrf2 level at 20 uM measured after 6 hrs by Western blot analysis
Activation of Nrf2 pathway in rat PC-12 cells assessed as increase in GCLM level at 20 uM measured after 6 hrs by Western blot analysis
Activation of Nrf2 pathway in rat PC-12 cells assessed as increase in HO-1 level at 20 uM measured after 6 hrs by Western blot analysis
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