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Binding affinity to recombinant human HSD17B10 assessed as shift in melting temperature by SYPRO orange dye based differential scanning fluorimetry assay
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of HSD17B10 (unknown origin) using estradiol as substrate incubated for 3 hrs and measured after 1 hr by NADH Glo luminescence assay
Assay data:15 Tested
SummaryRelated BioAssays by Target
Surface Plasmon Resonance (SPR)Assay from US Patent US9346839: "Phosphonate derivatives and methods of use thereof in the treatment of Alzheimer's disease"
Assay data:3 Active, 3 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
ABAD Enzymatic Activity Assay from US Patent US9346839: "Phosphonate derivatives and methods of use thereof in the treatment of Alzheimer's disease"
Assay data:5 Active, 1 Activity ≤ 1 µM, 8 Tested
Inhibition of recombinant mouse full-length 17beta-HSD10 (2 to 261 residues) assessed as reduction in transformation of [14C]-E2 to E1 after 48 hrs in presence of 1 mM NAD+ cofactor by liquid scintillation counting method
Assay data:3 Tested
Inhibition of recombinant mouse full-length 17beta-HSD10 (2 to 261 residues) assessed as reduction in transformation of [14C]-E2 to E1 at 300 uM after 48 hrs in presence of 1 mM NAD+ cofactor by liquid scintillation counting method relative to control
Assay data:14 Tested
Inhibition of recombinant mouse full-length 17beta-HSD10 (2 to 261 residues) assessed as reduction in transformation of [14C]-E2 to E1 at 100 uM after 48 hrs in presence of 1 mM NAD+ cofactor by liquid scintillation counting method
Assay data:16 Tested
Inhibition of recombinant mouse full-length 17beta-HSD10 (2 to 261 residues) assessed as reduction in transformation of [3H]-ALLOP to 5alpha-DHP after 48 hrs in presence of 1 mM NAD+ cofactor by liquid scintillation counting method
Inhibition of recombinant mouse full-length 17beta-HSD10 (2 to 261 residues) assessed as reduction in transformation of [3H]-ALLOP to 5alpha-DHP at 100 uM after 48 hrs in presence of 1 mM NAD+ cofactor by liquid scintillation counting method relative to control
Inhibition of human full length N-terminal GST-tagged 17beta-HSD10 expressed in Escherichia coli BL21 DE3 Codon plus using [6,7-3H]-labeled E2/E2 as substrate and NADH at 1 uM after 30 mins by HPLC based radioflow detection method
Inhibition of recombinant ABAD (unknown origin) assessed as remaining activity at 25 uM using acetoacetyl-CoA as substrate in presence of NADH by spectrophotometry
Assay data:47 Tested
qHTS Assay for Inhibitors of HSD17B4, hydroxysteroid (17-beta) dehydrogenase 4
Assay data:5711 Active, 80 Activity ≤ 1 µM, 75028 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS Assay for Inhibitors of HADH2 (Hydroxyacyl-Coenzyme A Dehydrogenase, Type II)
Assay data:2520 Active, 525 Activity ≤ 1 µM, 73252 Tested
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