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Inhibition of N-terminal His tagged human EP300 (1159-1666 residues) expressed in Escherichia coli BL21 (DE3) at 50 uM using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLISA assay relative to control
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of CBP (unknown origin) at 50 uM using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLISA assay relative to control
Inhibition of GST tagged human GCN5 (323 to end residues) expressed in Sf9 cells using biotinylated H3 (1 to 21)-GGK peptide as substrate incubated for 1 hr by AlphaLISA assay
Assay data:2 Tested
Inhibition of GST tagged human PCAF (431 to end residues) expressed in Sf9 cells using biotinylated H3 (1 to 21)-GGK peptide as substrate incubated for 1 hr by AlphaLISA assay
Inhibition of MYST4 (unknown origin) using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLISA assay
Inhibition of MYST2 (unknown origin) using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLISA assay
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of GST tagged human TIP60 expressed in Sf9 cells using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLISA assay
Inhibition of CBP (unknown origin) using biotinylated H4 (1 to 25)-GSGSK peptide as substrate incubated for 1 hr by AlphaLISA assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Competitive inhibition of p300 HAT domain (unknown origin) using varying concentrations of acetyl-CoA and constant concentration of H4-15 as substrates preincubated for 10 mins followed by substrate addition and measured after 10 mins
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of p300 HAT domain (unknown origin) using histone H4-15 peptide and acetyl-coA as substrates preincubated for 10 mins followed by substrate addition and measured after 10 mins
Assay data:1 Active, 1 Tested
Inhibition of EP300 (unknown origin) at 50 uM by AlphaLISA immunodetection assay relative to control
Assay data:5 Tested
Inhibition of EP300 (unknown origin) by AlphaLISA immunodetection assay
Assay data:4 Active, 16 Tested
Enzymatic assay of human HDAC6 with custom peptide substrate
Assay data:5603 Tested
SummaryRelated BioAssays by Target
Enzymatic assay of human HDAC6 with commercial peptide substrate
Inhibition of synthetic p300 HAT (unknown origin) expressed in Escherichia coli BL21(RIL)-DE3 using histone H4 15-mer N-terminal peptide as substrate preincubated for 10 mins followed by 14C-acetyl-CoA and measured after 10 mins by scintillation counting method
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Competitive inhibition of synthetic p300 (unknown origin) expressed in Escherichia coli BL21(RIL)-DE3 using H4-15 and acetyl-CoA as substrate
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Reactivity with glutathione assessed as addition product with thiol group measured within 1 hr by mass spectrometry
Reactivity with dithiothretol assessed as addition product with thiol group measured within 1 hr by mass spectrometry
Inhibition of p300 (unknown origin)
Inhibition of p300 in human U2932 cells assessed as reduction in H3K27 acetylation at 10 uM measured after 4 days in presence of EZH2 inhibitor EPZ6438 by Western blot analysis
Assay data:10 Active, 10 Tested
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