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Inhibition of FABP4 in mouse RAW264.7 cells assessed as decrease in LPS-induced IKK phosphorylation at 30 to 60 uM preincubated for 12 hrs followed by LPS addition and measured after 10 mins by Western blot analysis
Assay data:4 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of FABP4 in mouse RAW264.7 cells assessed as decrease in LPS-induced NF-kappaB phosphorylation at 30 to 60 uM preincubated for 12 hrs followed by LPS addition and measured after 10 mins by Western blot analysis
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced COX-2 gene expression level at 30 uM preincubated for 12 hrs followed by LPS addition and measured after 6 hrs by qRT PCR analysis
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed Citation
Antiinflammatory activity against mouse RAW264.7 cells assessed as inhibition of LPS-induced IL-6 gene expression level at 30 uM preincubated for 12 hrs followed by LPS addition and measured after 6 hrs by qRT PCR analysis
Inhibition of FABP4 in mouse 3T3L1 cells assessed as inhibition of forskolin-stimulated lipolysis at 30 uM preincubated for 24 hrs followed by forskolin addition and measured after 2 hrs
Cytotoxicity against mouse 3T3L1 cells assessed as reduction in cell viability at 30 to 60 uM incubated for 24 hrs by MTT assay
Assay data:4 Tested
SummaryPubMed Citation
Displacement of 1,8-ANS from human recombinant full length N-terminal his-tagged FABP4 expressed in Escherichia coli BL21 (DE3) incubated for 3 mins by fluorescence based assay
Assay data:24 Active, 26 Tested
Displacement of 1,8-ANS from human recombinant full length N-terminal his-tagged FABP5 expressed in Escherichia coli BL21 (DE3) at 25 uM incubated for 3 mins by fluorescence based assay relative to control
Assay data:35 Tested
SummaryPubMed CitationRelated BioAssays by Target
Displacement of 1,8-ANS from human recombinant full length N-terminal his-tagged FABP4 expressed in Escherichia coli BL21 (DE3) at 25 uM incubated for 3 mins by fluorescence based assay relative to control
Assay data:37 Tested
Cytotoxicity against mouse RAW264.7 cells assessed as reduction in cell viability at 30 to 60 uM incubated for 24 hrs by MTT assay
Antidiabetic activity in C57BL/Ksj db/db mouse assessed as reduction in fasting blood glucose level at 100 mg/kg, po administered once daily via lavage for 14 to 35 days relative to control
Assay data:2 Tested
Antidiabetic activity in C57BL/Ksj db/db mouse assessed as reduction in blood glucose AUC at 100 mg/kg, po administered once daily via lavage for 2 to 4 weeks followed by 12 hrs fasting and subsequent glucose challenge measured after 15 to 120 mins by OGTT method
Assay data:2 Active, 2 Tested
Antidiabetic activity in C57BL/Ksj db/db mouse assessed as reduction in blood glucose AUC at 100 mg/kg, po administered once daily via lavage for 2 to 4 weeks followed by 6 hrs fasting and subsequent insulin challenge measured after 30 to 120 mins by ITT method
Antidiabetic activity in C57BL/Ksj db/db mouse assessed as reduction in serum ALT levels at 100 mg/kg, po administered once daily via lavage for 2 to 4 weeks
Antidiabetic activity in C57BL/Ksj db/db mouse assessed as reduction in serum AST levels at 100 mg/kg, po administered once daily via lavage for 2 to 4 weeks
Antidiabetic activity in C57BL/Ksj db/db mouse assessed as reduction in serum triglyceride levels at 100 mg/kg, po administered once daily via lavage for 2 to 4 weeks
Antidiabetic activity in C57BL/Ksj db/db mouse assessed as reduction in serum non-esterified fatty acid levels at 100 mg/kg, po administered once daily via lavage for 2 to 4 weeks
Effect on total cholesterol levels in C57BL/Ksj db/db mouse at 100 mg/kg, po administered once daily via lavage for 2 to 4 weeks
Antidiabetic activity in C57BL/Ksj db/db mouse assessed as reduction in hepatic lipid accumulation at 100 mg/kg, po administered once daily via lavage for 2 to 4 weeks by hematoxylin and eosin staining based microscopic analysis
Antidiabetic activity in C57BL/Ksj db/db mouse assessed as reduction in liver inflammatory infiltration at 100 mg/kg, po administered once daily via lavage for 2 to 4 weeks by F4/80 staining based microscopic analysis
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