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Lipophilicity, log D of the compound
Assay data:22 Tested
SummaryPubMed Citation
Dissociation constant, pKa of the compound
Assay data:21 Tested
Inhibition of GARFT (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of DHFR (unknown origin) assessed as inhibition constant
Inhibition of thymidylate synthase (unknown origin) assessed as inhibition constant
Induction of hTS expression in human IGROV-1 cells assessed as fold increase at 5 uM measured after 48 hrs by immunoblot quantitative analysis
Assay data:1 Tested
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 4 (GPX4)
Assay data:258 Active, 16 Activity ≤ 1 µM, 11046 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1)
Assay data:186 Active, 9 Activity ≤ 1 µM, 11353 Tested
Inhibition Assay from US Patent US9422297: "Tricyclic compounds having cytostatic and/or cytotoxic activity and methods of use thereof"
Assay data:13 Active, 6 Activity ≤ 1 µM, 27 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibition of human thymidylate synthase expressed in Escherichia coli using 6R,S-tetrahydrofolate and dUMP as substrate by spectrophotometric analysis
Assay data:3 Active, 3 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Enzymatic assay of human HDAC6 with custom peptide substrate
Assay data:5603 Tested
SummaryRelated BioAssays by Target
Enzymatic assay of human HDAC6 with commercial peptide substrate
NCATS anti-infectives library activity on the primary C. elegans qHTS viability assay
Assay data:48 Active, 86 Activity ≤ 1 µM, 637 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
NCATS anti-infectives library activity on HEK293 viability as a counter-qHTS vs the C. elegans viability qHTS
Assay data:25 Active, 678 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
Primary qHTS for Inhibitors of ATXN expression
Assay data:2593 Active, 3 Activity ≤ 1 nM, 2671 Activity ≤ 1 µM, 361713 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of human full length N-terminal His-tagged ATIC expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formation using 10-CHOTHF as substrate by spectrophotometric method
Assay data:6 Active, 1 Activity ≤ 1 µM, 10 Tested
Inhibition of human full length N-terminal His-tagged GARFTase expressed in Chinese Hamster MTXRII-OuaR2-4 R2 cells assessed as reduction in THF formation using 10-CHOTHF as substrate by spectrophotometric method
Assay data:7 Active, 2 Activity ≤ 1 µM, 10 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
Assay data:2 Activity ≤ 1 µM, 4309 Tested
SummaryCompounds, activity ≤ 1 µM
Primary qHTS assay for inhibitors of alpha-synuclein gene (SNCA) expression
Assay data:237 Active, 1947 Activity ≤ 1 µM, 141380 Tested
GF-AFC viability counterscreen for inhibitors of alpha-synuclein gene (SNCA) expression
Assay data:177 Active, 2 Activity ≤ 1 nM, 481 Activity ≤ 1 µM, 146379 Tested
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