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Kinetic solubility of the compound in pH 2 HCl after 30 mins by nephelometry
Assay data:7 Tested
SummaryPubMed Citation
Kinetic solubility of the compound in pH 6.5 phosphate buffer after 30 mins by nephelometry
Partition coefficient, logD of compound at pH 7.4 by HPLC analysis
Assay data:8 Tested
Inhibition of Arabidopsis thaliana SHMT using L-serine/(6S)-THF as substrate after 20 mins by methylene tetrahydrofolate dehydrogenase coupled enzyme assay
Assay data:20 Active, 1 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 23 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Half life in human liver microsomes by LC/MS analysis
Assay data:21 Tested
Inhibition of Plasmodium falciparum SHMT using L-serine/(6S)-THF as substrate by methylene tetrahydrofolate dehydrogenase coupled enzyme assay
Assay data:42 Active, 36 Activity ≤ 1 µM, 42 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antimalarial activity against Plasmodium falciparum NF54 infected in human RBC assessed as reduction in [3H]hypoxanthine incorporation preincubated for 48 hrs followed by [3H]hypoxanthine addition measured after 24 hrs by liquid scintillation counting
Assay data:53 Active, 52 Activity ≤ 1 µM, 53 Tested
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