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Drug uptake in 12 hrs fasted ICR mouse assessed as plasma concentration at 30 mg/kg, ip measured after 6 hrs by LC-MS/MS analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Hypoglycemic activity in ICR mouse assessed as improvement in glucose tolerance at 10 to 30 mg/kg, ip administered after oral glucose at 2 g/kg and measured after 0.25 hr by OGTT
Cytotoxicity in ICR mouse serum starved primary hepatocytes assessed as reduction in cell viability at 50 to 300 uM
Assay data:1 Tested
SummaryPubMed Citation
Inhibition of human FBPase in ICR mouse serum starved primary hepatocytes assessed as glucose lowering effect
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Hypoglycemic activity in 12 hrs fasted ICR mouse assessed as reduction in blood glucose AUC (0 to 2 hrs) at 30 mg/kg, ip measured after 2 hrs
Hypoglycemic activity in 12 hrs fasted ICR mouse assessed as reduction in blood glucose AUC (0 to 2 hrs) at 10 mg/kg, ip measured after 2 hrs
Hypoglycemic activity in 12 hrs fasted ICR mouse assessed as reduction in blood glucose AUC (0 to 6 hrs) at 30 mg/kg, ip measured after 6 hrs
Hypoglycemic activity in 12 hrs fasted ICR mouse assessed as reduction in blood glucose AUC (0 to 6 hrs) at 10 mg/kg, ip measured after 6 hrs
Hypoglycemic activity in 12 hrs fasted ICR mouse assessed as glucose lowering effect at 10 to 30 mg/kg, ip measured after 2 hrs
Hypoglycemic activity in ICR mouse assessed as glucose lowering effect at 30 mg/kg, ip measured after 2 to 6 hrs
Inhibition of BTK (unknown origin) at 300 uM measured after 40 mins in presence of ATP by luminescence assay relative to control
Assay data:2 Tested
SummaryPubMed CitationRelated BioAssays by Target
Selectivity ratio of IC50 for human FBPase to IC50 for human GAPDH
Assay data:6 Tested
Selectivity ratio of IC50 for human FBPase to IC50 for recombinant ALDOC (unknown origin)
Selectivity ratio of IC50 for human FBPase to IC50 for recombinant ALDOB (unknown origin)
Selectivity ratio of IC50 for human FBPase to IC50 for recombinant ALDOA (unknown origin)
Inhibition of EGFR (unknown origin) at 300 uM measured after 40 mins in presence of ATP by luminescence assay relative to control
Inhibition of human FBPase expressed Escherichia coli BL21 in by malachite green dye based spectrophotometry
Assay data:7 Active, 9 Tested
Half life of the compound in GSH
Assay data:21 Tested
Half life of the compound in DMSO
Assay data:23 Tested
Half life of the compound in buffer
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