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Antiproliferative activity against human Hs-578T cells transfected with LY6K-shRNA assessed as reduction in cell viability at 5 to 10 uM measured after 48 hrs by Cell titer blue assay
Assay data:3 Tested
SummaryPubMed Citation
Inhibition of LY6K in human Hs-578T cells assessed as reduction in cell viability measured after 48 hrs by Cell titer blue assay
Binding affinity to human wild type LY6K assessed as dissociation constant measured upto 250 sec by SPR assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Binding affinity to human wild type LY6K at 1.25 to 5 uM measured upto 250 sec by SPR assay
Assay data:3 Active, 5 Tested
SummaryCompounds, ActivePubMed Citation
Effect on total Ly6K levels in mouse 4T1 cells at 0.1 to 5 mM measured by Western blotting analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, Active
Induction of autophagy in mouse 4T1 cells at 0.1 to 5 uM assessed as activation of LC3B measured after 16 hrs by Western blot analysis
Down regulation of RhoA in mouse 4T1 cells at 0.1 to 5 uM measured after 16 hrs by Western blot analysis
Induction of apoptosis in mouse 4T1 cells at 0.1 to 5 uM assessed as activation of caspase-7 measured after 16 hrs by Western blot analysis
Induction of apoptosis in mouse 4T1 cells at 0.1 to 5 uM assessed as activation of caspase-3 measured after 16 hrs by Western blot analysis
Induction of apoptosis in mouse 4T1 cells at 0.1 to 5 uM assessed as increase in PARP cleavage measured after 16 hrs by Western blot analysis
Cell cycle arrest in mouse 4T1 cells assessed as accumulation at 4n phase at 5 uM (Rvb = 0.47%)
Assay data:1 Tested
Summary
Cell cycle arrest in mouse 4T1 cells assessed as accumulation at G2 phase at 5 uM (Rvb = 22.7%)
Cell cycle arrest in mouse 4T1 cells assessed as accumulation at S phase at 5 uM (Rvb = 18.8%)
Cell cycle arrest in mouse 4T1 cells assessed as accumulation at G1 phase at 5 uM (Rvb = 58.1%)
Cell cycle arrest in mouse 4T1 cells assessed as accumulation at sub G1 phase at 5 uM (Rvb = 0.4%)
Cell cycle arrest in mouse 4T1 cells assessed as accumulation at 4n phase at 1 uM (Rvb = 0.47%)
Cell cycle arrest in mouse 4T1 cells assessed as accumulation at G2 phase at 1 uM (Rvb = 22.7%)
Cell cycle arrest in mouse 4T1 cells assessed as accumulation at S phase at 1 uM (Rvb = 18.8%)
Cell cycle arrest in mouse 4T1 cells assessed as accumulation at G1 phase at 1 uM (Rvb = 58.1%)
Cell cycle arrest in mouse 4T1 cells assessed as accumulation at sub G1 phase at 1 uM (Rvb = 0.4%)
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