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Toxicity in Balb/c mouse infected with Epstein-Barr virus positive human Raji cells assessed as body weight loss at 5 to 10 mg/kg, sc administered every 3 days for 25 days and measured every 3 days before drug injection
Assay data:1 Tested
SummaryPubMed Citation
Antiviral activity against Epstein-Barr virus positive human Raji cells xenografted in Balb/c mouse assessed as reduction in EBV DNA copy at 5 to 10 mg/kg, sc administered every 3 days for 25 days
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of Epstein-Barr virus-induced human Raji cell proliferation xenografted in Balb/c mouse assessed as reduction in tumor size at 10 mg/kg, sc administered every 3 days for 25 days and measured every 3 days before drug injection
Inhibition of Epstein-Barr virus-induced human Raji cell proliferation xenografted in Balb/c mouse assessed as reduction in tumor size at 5 mg/kg, sc administered every 3 days for 25 days and measured every 3 days before drug injection
Inhibition of EBNA1 binding to Epstein-Barr virus OriP DNA in human Raji cells assessed as reduction in EBNA2 protein expression up to 20 uM after 24 hrs by Western blot analysis
Assay data:2 Tested
Inhibition of EBNA1 binding to Epstein-Barr virus OriP DNA in human Raji cells assessed as reduction in EBNA1 protein expression up to 20 uM after 24 hrs by Western blot analysis
Inhibition of EBNA1 binding to Epstein-Barr virus OriP DNA in human Raji cells at 10 uM after 24 to 48 hrs by chIP assay
Assay data:1 Active, 2 Tested
Inhibition of EBNA1 binding to Epstein-Barr virus OriP DNA in human B95-8 cells assessed as reduction in EBV copy number at 10 uM after 120 hrs by qRT-PCR analysis
Inhibition of EBNA1 binding to Epstein-Barr virus OriP DNA in human Daudi cells assessed as reduction in EBV copy number at 10 uM after 120 hrs by qRT-PCR analysis
Inhibition of EBNA1 binding to Epstein-Barr virus OriP DNA in human Raji cells assessed as reduction in EBV copy number at 10 uM after 120 hrs by qRT-PCR analysis
Assay data:1 Active, 3 Tested
Cell growth inhibition of human MDA-MB-231 cells after 72 hrs by MTT assay
Cell growth inhibition of human Jurkat cells after 72 hrs by MTT assay
Cell growth inhibition of human MOLT4 cells after 72 hrs by MTT assay
Cell growth inhibition of human RPMI8226 cells after 72 hrs by MTT assay
Cell growth inhibition of human NALM6 cells after 72 hrs by MTT assay
Inhibition of Epstein-Barr virus-induced human B95-8 cell proliferation after 72 hrs by MTT assay
Inhibition of Epstein-Barr virus-induced human Raji cell proliferation after 72 hrs by MTT assay
Inhibition of Epstein-Barr virus-induced human Daudi cell proliferation after 72 hrs by MTT assay
Cell growth inhibition of human MOLT4 cells at 10 uM measured at day 3 and day 6 following media refreshment every 3 days by trypan blue dye-based assay
Cell growth inhibition of human Jurkat cells at 10 uM measured at day 3 and day 6 following media refreshment every 3 days by trypan blue dye-based assay
Assay data:2 Active, 2 Tested
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