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Positive allosteric modulation of GluN1/N2A in glutamate-induced excitotoxicity rat PC12 cell model assessed as increase in CREB phosphorylation at Ser133 at 1 uM measured after 24 hrs in presence of NVP-AAM077 by Western blot analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Positive allosteric modulation of GluN1/N2A in glutamate-induced excitotoxicity rat PC12 cell model assessed as increase in CREB phosphorylation at Ser133 at 1 uM measured after 24 hrs by Western blot analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Neuroprotective activity against tMCAO-reperfusion induced nerve injury in C57BL/6 mouse model assessed as recovery of neurological deficit score at 5 to 10 mg/kg, ip measured after 22 hrs
SummaryCompounds, ActivePubMed Citation
Neuroprotective activity against tMCAO-reperfusion induced nerve injury in C57BL/6 mouse model assessed as reduction in volume of ischemia cerebral infarction at 10 mg/kg, ip measured after 22 hrs by TTC staining based analysis (Rvb = 130.60 +/- 9.93 mm3)
Assay data:2 Tested
SummaryPubMed Citation
Neuroprotective activity against tMCAO-reperfusion induced nerve injury in C57BL/6 mouse model assessed as reduction in volume of ischemia cerebral infarction at 5 mg/kg, ip measured after 22 hrs by TTC staining based analysis (Rvb = 130.60 +/- 9.93 mm3)
Neuroprotective activity against tMCAO-reperfusion induced nerve injury in C57BL/6 mouse model assessed as reduction in volume of ischemia cerebral infarction at 10 mg/kg, ip measured after 22 hrs by TTC staining based analysis relative to control
Neuroprotective activity against tMCAO-reperfusion induced nerve injury in C57BL/6 mouse model assessed as reduction in volume of ischemia cerebral infarction at 5 mg/kg, ip measured after 22 hrs by TTC staining based analysis relative to control
Cytotoxicity against mouse HT-22 cells assessed as cell viability at 10 uM incubated for 4 hrs by CCK8 assay relative to control
Assay data:10 Tested
Neuroprotective activity against glutamate-induced excitotoxicity in mouse HT-22 cells assessed as cell viability at 10 uM preincubated for 4 hrs followed by glutamate treatment for 24 hrs by CCK8 assay (Rvb = 34.80 +/- 4.02 %)
Neuroprotective activity against glutamate-induced excitotoxicity in mouse HT-22 cells assessed as cell viability at 1 uM preincubated for 4 hrs followed by glutamate treatment for 24 hrs by CCK8 assay (Rvb = 35.56 +/- 2.12 %)
Neuroprotective activity against glutamate-induced excitotoxicity in mouse HT-22 cells assessed as cell viability at 0.1 uM preincubated for 4 hrs followed by glutamate treatment for 24 hrs by CCK8 assay (Rvb = 30.31 +/- 2.02 %)
Cytotoxicity against rat PC12 cells assessed as cell viability at 10 uM incubated for 4 hrs by CCK8 assay relative to control
Neuroprotective activity against glutamate-induced excitotoxicity in rat PC12 cells assessed as cell viability at 10 uM preincubated for 4 hrs followed by glutamate treatment for 24 hrs by CCK8 assay (Rvb = 43.75 +/- 2.04 %)
Neuroprotective activity against glutamate-induced excitotoxicity in rat PC12 cells assessed as cell viability at 1 uM preincubated for 4 hrs followed by glutamate treatment for 24 hrs by CCK8 assay (Rvb = 43.19 +/- 2.98 %)
Neuroprotective activity against glutamate-induced excitotoxicity in rat PC12 cells assessed as cell viability at 0.1 uM preincubated for 4 hrs followed by glutamate treatment for 24 hrs by CCK8 assay (Rvb = 44.89 +/- 2.08 %)
Positive allosteric modulation of GluN1/N2A/N2B (unknown origin) transfected in HEK293 cells assessed as potentiation of Glu/Gly-induced calcium influx by Cal-520 AM dye based assay
Positive allosteric modulation of GluN1/N2B (unknown origin) transfected in HEK293 cells assessed as potentiation of Glu/Gly-induced calcium influx by Cal-520 AM dye based assay
Assay data:23 Tested
Positive allosteric modulation of GluN1/N2A (unknown origin) transfected in HEK293 cells assessed as potentiation of Glu/Gly-induced calcium influx by Cal-520 AM dye based assay
Assay data:1 Active, 2 Tested
Cell-based high-throughput assay to identify small molecules that inhibit phospholipid biosynthesis in animal cells 2: screen of the Analyticon library.
Assay data:3 Active, 495 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
EZH2/PRC2 methyltransferase inhibitors Measured in Biochemical System Using Plate Reader - 2125-01_Inhibitor_SinglePoint_HTS_Activity
Assay data:201 Active, 57246 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
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