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Cytotoxicity against human HEK293 cells assessed as cell viability at 50 uM measured after 24 hrs by Alamar Blue assay
Assay data:15 Tested
SummaryPubMed Citation
Induction of apoptosis in human MV4-11 cells at 2 to 15 uM measured after 24 hrs by Annexin V-FITC/propidium iodide staining based flow cytometry
Assay data:2 Tested
Induction of autophagy in human MV4-11 cells assessed as change in GAPDH level at 2 to 15 uM measured by immunoblotting method
Induction of autophagy in human MV4-11 cells assessed as slight increase in HDAC10 at 2 to 15 uM measured by immunoblotting method
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of HDAC6 in human MV4-11 cells assessed as fold-induction of tubulin acetylation at 15 uM measured by immunoblotting method
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human HDAC8 using H2N-Arg- His-Lys(Ac)-Lys(Ac)-AMC as substrate incubated for 90 mins and measured after 20 mins by fluorescence assay
Assay data:12 Active, 5 Activity ≤ 1 µM, 14 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant human HDAC6 using ZMAL (Z-(Ac)Lys-AMC as substrate incubated for 20 mins and measured by homogenous fluorescence assay
Assay data:11 Active, 6 Activity ≤ 1 µM, 14 Tested
Inhibition of recombinant human HDAC1 using ZMAL (Z-(Ac)Lys-AMC as substrate incubated for 20 mins at 1 uM and measured by homogenous fluorescence assay relative to control
Assay data:10 Tested
Inhibition of recombinant human HDAC1 using ZMAL (Z-(Ac)Lys-AMC as substrate incubated for 20 mins at 10 uM and measured by homogenous fluorescence assay relative to control
Inhibition of zebra fish HDAC10 using Ac-spermidine-AMC as substrate incubated for 25 mins and measured by fluorescence assay
Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested
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