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Toxicity in TH-MYCN +/+ transgenic neuroblastoma 129x1/SvJ.Tg (TH-MYCN)41Waw/Nci mouse model assessed as effect on CD11b+ cells population at 10 mg/kg, ip qd by flow cytometry
Assay data:1 Tested
SummaryPubMed Citation
Toxicity in TH-MYCN +/+ transgenic neuroblastoma 129x1/SvJ.Tg (TH-MYCN)41Waw/Nci mouse model assessed as effect on patrolling monocytes/DC+ cells population at 10 mg/kg, ip qd by flow cytometry
Toxicity in TH-MYCN +/+ transgenic neuroblastoma 129x1/SvJ.Tg (TH-MYCN)41Waw/Nci mouse model assessed as effect on macrophage population at 10 mg/kg, ip qd by flow cytometry
Toxicity in TH-MYCN +/+ transgenic neuroblastoma 129x1/SvJ.Tg (TH-MYCN)41Waw/Nci mouse model assessed as effect on CD8+ cells population at 10 mg/kg, ip qd by flow cytometry
Toxicity in TH-MYCN +/+ transgenic neuroblastoma 129x1/SvJ.Tg (TH-MYCN)41Waw/Nci mouse model assessed as effect on CD4+ cells population at 10 mg/kg, ip qd by flow cytometry
Toxicity in TH-MYCN +/+ transgenic neuroblastoma 129x1/SvJ.Tg (TH-MYCN)41Waw/Nci mouse model assessed as effect on CD45+ cells population at 10 mg/kg, ip qd by flow cytometry
Anti-tumor activity against tumor cells in TH-MYCN +/+ neuroblastoma 129x1/SvJ.Tg (TH-MYCN)41Waw/Nci mouse model assessed as reduction in tumor weight at 10 mg/kg, ip measured on day 7 by ultrasound imaging analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Anti-tumor activity against tumor cells in TH-MYCN +/+ neuroblastoma 129x1/SvJ.Tg (TH-MYCN)41Waw/Nci mouse model assessed as reduction in tumor volume administered intraperitoneally measured on day 7 by ultrasound imaging analysis
Anti-tumor activity against TH-MYCN +/+ transgenic neuroblastoma 129x1/SvJ.Tg (TH-MYCN)41Waw/Nci mouse model assessed as reduction in tumor growth at 10 mg/kg, ip measured upto 7 days by ultrasound imaging analysis
Cytotoxicity against tumor cells in TH-MYCN +/+ transgenic neuroblastoma 129x1/SvJ.Tg (TH-MYCN)41Waw/Nci mouse model assessed as reduction in viability of tumor spheres measured after 3 days by light microscopy
Cytotoxicity against tumor cells in TH-MYCN +/+ transgenic neuroblastoma 129x1/SvJ.Tg (TH-MYCN)41Waw/Nci mouse model assessed as reduction in cell viability at 0.1 to 10 uM measured after 3 days by MTS assay
Anti-tumor activity against human BE2C cells xenografted in NSG mouse assessed as reduction in tumor volume at 10 mg/kg, ip measured for 5 to 8 days
Anti-tumor activity against human SH-SY5Y cells xenografted in NSG mouse assessed as reduction in tumor volume at 10 mg/kg, ip measured for 5 to 10 days
Antagonist activity at VDR in human BE2C cells assessed as reduction in cyclin-D expression at 1 uM incubated for 24 hrs by western blot analysis relative to control
SummaryPubMed CitationRelated BioAssays by Target
Antagonist activity at VDR in human BE2C cells assessed as reduction in MYCN expression at 1 uM incubated for 24 hrs by western blot analysis relative to control
Downregulation of VDR expression in human BE2C cells at 1 uM incubated for 24 hrs by western blot analysis relative to control
Cytotoxicity against human SH-SY5Y cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against human Kelly cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against human BE2C cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
Cytotoxicity against human SK-N-AS cells assessed as reduction in cell viability incubated for 48 hrs by MTS assay
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