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Inhibition of human DHFR mutant by spectrophotometric assay
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of Pneumocystis carinii DHFR K37Q/F69N mutant by spectrophotometric assay
Inhibition of Pneumocystis carinii DHFR K37Q mutant by spectrophotometric assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of recombinant Pneumocystis carinii DHFR expressed in Escherichia coli Rosetta Gami B (DE3) by spectrophotometric assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of recombinant Pneumocystis jirovecii DHFR expressed in Escherichia coli Rosetta Gami B (DE3) by spectrophotometric assay
Inhibition of recombinant human DHFR expressed in Escherichia coli Rosetta Gami B (DE3) by spectrophotometric assay
Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB
Assay data:3598 Active, 421 Activity ≤ 1 nM, 2233 Activity ≤ 1 µM, 3598 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Selectivity ratio of Pneumocystis carinii DHFR over rat liver DHFR
Assay data:2 Tested
SummaryPubMed Citation
Selectivity ratio of Toxoplasma gondii DHFR over rat liver DHFR
Inhibition of Pneumocystis jirovecii DHFR
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Selectivity ratio of Pneumocystis jirovecii DHFR over rat liver DHFR
Ratio of inhibitory activity against dihydrofolate reductase of rat liver to Toxoplasma gondii
Assay data:19 Tested
Ratio of inhibitory activity against dihydrofolate reductase of rat liver to pneumocystis carinii
Assay data:20 Tested
Inhibitory activity against cell growth of Toxoplasma gondii by direct counting of organisms in the culture supernatant fluid at 4.2 uM
Assay data:1 Tested
In vivo cytotoxic evaluation against melanoma SK-MEL-5 cell line
Assay data:4 Active, 1 Activity ≤ 1 µM, 4 Tested
In vivo cytotoxic evaluation against CNS cancer SF-295 cell line
Inhibitory activity against cell growth of pneumocystis carinii measured by the incorporation of [3H]uracil at 10 uM
In vivo cytotoxic evaluation against human leukemic Molt-4 cell line
In vivo cytotoxic evaluation against breast cancer MDA-N cell line
Assay data:4 Active, 2 Activity ≤ 1 µM, 4 Tested
In vivo cytotoxic evaluation against breast cancer MDA-MB-435 cell line
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