BioAssays for PubChem Compound (Select 51001932) - PubChem BioAssay - NCBI

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Select item 19620161.

Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.

Source:: ChEMBL

Assay data:1241 Active, 184 Activity ≤ 1 µM, 1545 Tested

AID:: 1962016

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 19189692.

Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress

Source:: ICCB-Longwood Screening Facility, Harvard Medical School

Assay data:281 Active, 189401 Tested

AID:: 1918969

Summary Compounds, Active

Select item 19137953.

Selectivity interaction (SelectScreen panel (Invitrogen)) EUB0000685a PIK3CG

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Assay data:1 Tested

AID:: 1913795

Summary Related BioAssays by Target

Select item 19137944.

Selectivity interaction (SelectScreen panel (Invitrogen)) EUB0000685a PIK3CD

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Tested

AID:: 1913794

Summary Related BioAssays by Target

Select item 19137935.

Selectivity interaction (SelectScreen panel (Invitrogen)) EUB0000685a PIK3CA

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Assay data:1 Tested

AID:: 1913793

Summary Related BioAssays by Target

Select item 19137926.

Selectivity interaction (SelectScreen panel (Invitrogen)) EUB0000685a PIK3C3

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 3-kinase catalytic subunit type 3

Assay data:1 Tested

AID:: 1913792

Summary Related BioAssays by Target

Select item 19137917.

Selectivity interaction (Enzymatic assay) EUB0000685a PIK3C3

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 3-kinase catalytic subunit type 3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913791

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19137908.

Selectivity interaction (SelectScreen panel (Invitrogen)) EUB0000685a PIK3C2B

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

Assay data:1 Tested

AID:: 1913790

Summary Related BioAssays by Target

Select item 19137899.

Selectivity interaction (Enzymatic assay) EUB0000685a PIK3C2B

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913789

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191313610.

Affinity Biochemical interaction (Enzymatic fluorescence polarization assay) EUB0000685a PIK3CG

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913136

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191313511.

Affinity Biochemical interaction (Enzymatic fluorescence polarization assay) EUB0000685a PIK3CD

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913135

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191313412.

Affinity Biochemical interaction (Enzymatic fluorescence polarization assay) EUB0000685a PIK3CB

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913134

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191313313.

Affinity Biochemical interaction (Enzymatic fluorescence polarization assay) EUB0000685a PIK3CA

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913133

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191272014.

Affinity Phenotypic Cellular interaction (MesoScale Discovery assay (AKT phoshorylation in MCF 7 cells)) EUB0000685a PIK3CG

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912720

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191271915.

Affinity Phenotypic Cellular interaction (MesoScale Discovery assay (AKT phoshorylation in MCF 7 cells)) EUB0000685a PIK3CD

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912719

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191271816.

Affinity Phenotypic Cellular interaction (MesoScale Discovery assay (AKT phoshorylation in MCF 7 cells)) EUB0000685a PIK3CB

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912718

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191271717.

Affinity Phenotypic Cellular interaction (MesoScale Discovery assay (AKT phoshorylation in MCF 7 cells)) EUB0000685a PIK3CA

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912717

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 189760418.

Selectivity ratio of IC90 for inhibition of PI3Kdelta in human B-cells assessed as reduction in CD69 expression to EC50 for inhibition of PI3Kalpha H1047R mutant in human HCC1954 cells

Source:: ChEMBL

Assay data:5 Tested

AID:: 1897604

Summary PubMed Citation

Select item 189760319.

Inhibition of PI3Kdelta in human B-cells assessed as reduction in CD69 expression preincubated for 1 hr followed by IgM stimulation for 18 hrs by flow cytometry analysis

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1897603

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 189759420.

Lipophilicity, logD of compound in 1-Octanol/PBS at pH 7.4 by LC-MS/MS method

Source:: ChEMBL

Assay data:31 Tested

AID:: 1897594

Summary PubMed Citation

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Target

Proteins (19)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (190)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (21)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (54)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (127)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (60)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (2)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (74)
BioAssays extracted from the literature
NIH MLP (20)
BioAssays deposited by the NIH Molecular Libraries Program
Other (188)
BioAssays deposited by other experimentalists

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