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Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Assay data:281 Active, 189401 Tested
SummaryCompounds, Active
Phosphodiesterase (PDE) Inhibition Assay from Article 10.1038/nbt1059: "A family of phosphodiesterase inhibitors discovered by cocrystallography and scaffold-based drug design."
Assay data:9 Active, 6 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mitochondria
Assay data:128 Active, 5056 Tested
SummaryCompounds, ActivePubMed Citation
Inhibition of human His-tagged PDE4D catalytic domain expressed in Escherichia coli BL21-CodonPlus(DE3) cells using [3H]cAMP or [3H]cGMP as substrate incubated for 30 mins by scintillation counting method
Assay data:9 Active, 2 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 10 Tested
MELAS cybrid survival enhancement under low glucose conditions
Assay data:264 Active, 4937 Tested
Lung cancer cell sensitization to miR-34 therapy: cell viability screen of compounds
Assay data:58 Active, 9908 Tested
Dicer-mediated maturation of pre-microRNA
Assay data:2829 Active, 46808 Tested
Inhibitors of CDC25B-CDK2/CyclinA interaction
Assay data:680 Active, 93851 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB
Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Maybridge screen to identify antagonists of kappa opioid receptor 1 (OPRK1): fluorescence-based cell-based assay
Assay data:72 Active, 16000 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
A screen for compounds that modulate the activity of the Staphylococcus aureus MgrA protein
Assay data:107 Active, 83548 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
A screen for compounds that inhibit the CapD enzyme of Bacillus anthracis
Assay data:320 Active, 139468 Tested
Cell-based luminescence-based Maybridge primary high throughput screening assay to identify agonists of NOTCH
Assay data:61 Active, 15360 Tested
Fluorescence polarization-based Maybridge primary biochemical high throughput screening assay to identify inhibitors of Protein Phosphatase Methylesterase 1 (PME-1).
Assay data:73 Active, 16000 Tested
Luminescence-based counterscreen for inhibitors of NADPH oxidase 1 (Nox1): biochemical high throughput screening assay to identify inhibitors of luminol (Maybridge Library)
Assay data:70 Active, 16000 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same Project
Luminescence-based primary cell-based high throughput screening assay to identify inhibitors of NADPH oxidase 1 (Nox1): Maybridge Library
Assay data:130 Active, 16000 Tested
Primary cell-based high-throughput screening assay to identify agonists of Sphingosine 1-Phosphate receptor 1 (S1P1)
Assay data:243 Active, 15999 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Primary Cell Based High Throughput Screening Assay for Agonists of GALR2
Assay data:79 Active, 16000 Tested
Primary Cell Based High Throughput Screening Assay for Inhibitors of TLR4-MyD88 binding
Assay data:10 Active, 15680 Tested
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