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Inhibition of Rock2 (unknown origin) assessed as inhibition constant
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Induction of disruption of actin stress fibers in human TM1 cells by actin stress fiber assay
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Induction of disruption of actin stress fibers in PTM cells by actin stress fiber assay
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of Rock2 (unknown origin) by Kinase Glo luminescence assay
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Inhibition of Rock1 (unknown origin) by Kinase Glo luminescence assay
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 4 (GPX4)
Assay data:258 Active, 16 Activity ≤ 1 µM, 11046 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1)
Assay data:186 Active, 9 Activity ≤ 1 µM, 11353 Tested
ROCK-II(h) In Vitro Inhibition Activity from US Patent US11485707: "Deuterated compounds as rock inhibitors"
ROCK-I(h) In Vitro Inhibition Activity-Method A from US Patent US11485707: "Deuterated compounds as rock inhibitors"
Inhibition of human ROCK2 by Kinase-Glo luminescent assay
Half life in cynomolgus monkey cornea by HPLC analysis
Assay data:1 Tested
SummaryPubMed Citation
Half life in Beagle dog cornea by HPLC analysis
Half life in Dutch Belted rabbit cornea by HPLC analysis
Half life in human cornea by HPLC analysis
Half life in pig cornea by HPLC analysis
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)
Assay data:2970 Active, 9 Activity ≤ 1 nM, 1016 Activity ≤ 1 µM, 10037 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)
Assay data:2826 Active, 4 Activity ≤ 1 nM, 946 Activity ≤ 1 µM, 10037 Tested
Primary qHTS for Inhibitors of N-terminal methyltransferase 1 (NTMT1): MTaseGlo Assay
Assay data:1477 Active, 244 Activity ≤ 1 µM, 58936 Tested
Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry
Assay data:368 Active, 78 Activity ≤ 1 µM, 5114 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry
Assay data:158 Active, 29 Activity ≤ 1 µM, 5114 Tested
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