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Inhibition of human his tagged USP14 assessed as dissociation constant by SPR analysis
Assay data:1 Tested
SummaryPubMed CitationRelated BioAssays by Target
Inhibition of human his tagged UCHL5 assessed as dissociation constant by SPR analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Inhibition of human his tagged USP14 by SPR analysis
Cytotoxicity against human multiple myeloma cells by WST-1 assay
Assay data:13 Active, 1 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 17 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 4 (GPX4)
Assay data:258 Active, 16 Activity ≤ 1 µM, 11046 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1)
Assay data:186 Active, 9 Activity ≤ 1 µM, 11353 Tested
NCATS anti-infectives library activity on the primary C. elegans qHTS viability assay
Assay data:48 Active, 86 Activity ≤ 1 µM, 637 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
NCATS anti-infectives library activity on HEK293 viability as a counter-qHTS vs the C. elegans viability qHTS
Assay data:25 Active, 678 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)
Assay data:2970 Active, 9 Activity ≤ 1 nM, 1016 Activity ≤ 1 µM, 10037 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)
Assay data:2826 Active, 4 Activity ≤ 1 nM, 946 Activity ≤ 1 µM, 10037 Tested
Primary qHTS for Inhibitors of N-terminal methyltransferase 1 (NTMT1): MTaseGlo Assay
Assay data:1477 Active, 244 Activity ≤ 1 µM, 58936 Tested
Primary qHTS to identify inhibitors of SARS-CoV-2 cell entry
Assay data:368 Active, 78 Activity ≤ 1 µM, 5114 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
Cytotoxicity counterscreen for inhibitors of SARS-CoV-2 cell entry
Assay data:158 Active, 29 Activity ≤ 1 µM, 5114 Tested
Inhibition of CIAPIN1 in human KMS11 cells assessed as deletion of depletion of stable CIAPIN1 levels at 100 nM incubated for 6 hrs by immunoblot analysis
Inhibition of CIAPIN1 in human KMS11 cells assessed as induction of high molecular weight complex formation at 100 nM incubated for 6 hrs by immunoblot analysis
Inhibition of CIAPIN1 in human KMS11 cells assessed as induction of protein aggregation at 100 nM incubated for 1 hr by immunoblot analysis
Inhibition of recombinant purified CIAPIN1 (unknown origin) assessed as disruption of intra-chain disulfide bond in unmodified peptide containing Cys249
Inhibition of recombinant purified CIAPIN1 (unknown origin) assessed as covalent modification of cysteine residues incubated for 2 hrs LC-MS/MS analysis
Inhibition of recombinant purified CIAPIN1 (unknown origin) assessed as covalent adduct formation at 10 molar equivalents incubated for 2 hrs by electrospray MS analysis
Inhibition of recombinant purified CIAPIN1 (unknown origin) assessed as increase in high molecular weight CIAPIN1 complexes at 1 to 10 molar equivalent 1 by SDS-PAGE and Coomassie Blue staining based method
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