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Selectivity index, ratio of IC50 for cytotoxicity against Chinese hamster CHO-K1 cells to MIC for antimycobacterial activity against Mycobacterium tuberculosis H37Rv
Assay data:7 Tested
SummaryPubMed Citation
Cytotoxicity against Chinese hamster CHO-K1 cells assessed as inhibition of cell growth
Antimycobacterial activity against Mycobacterium tuberculosis H37Rv
Assay data:21 Active, 4 Activity ≤ 1 µM, 93 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
High-throughput screening primary assay to identify small molecule activators of human guanylyl cyclase B (GC-B) receptor activity
Assay data:399 Active, 370620 Tested
SummaryCompounds, Active
Discovery of Small Molecules to Inhibit Human Cytomegalovirus Nuclear Egress
Assay data:281 Active, 189401 Tested
Thymidine Phosphorylase Inhibition Assay from Article 10.1016/j.bioorg.2015.04.003: "Synthesis, thymidine phosphorylase inhibition and molecular modeling studies of 1,3,4-oxadiazole-2-thione derivatives."
Assay data:11 Tested
Primary qHTS for Inhibitors of ATXN expression
Assay data:2593 Active, 3 Activity ≤ 1 nM, 2671 Activity ≤ 1 µM, 361713 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
High-throughput screening primary assay to identify small molecule activators of human GC-A enzyme activity
Assay data:519 Active, 370620 Tested
Primary qHTS assay for inhibitors of human arachidonate 12S-lipoxygenase (ALOX12): Round 2
Assay data:6069 Active, 5332 Activity ≤ 1 µM, 575118 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
Assay data:7212 Tested
Summary
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20 M by FRET kind of response from peptide substrate
SummaryRelated BioAssays by Target
Drug level in DTT containing buffer treated with 3-((5-Phenyl-1,3,4-oxadiazol-2-yl)thio)benzo[b]thiophene-1,1-dioxide by LC-MS analysis
Assay data:2 Tested
Antagonist identification of Pyk2 oligomerization: high-throughput screening cellular assay
Assay data:818 Active, 98760 Tested
Cell-based high-throughput assay to identify small molecules that inhibit phospholipid biosynthesis in animal cells 3: screen of the Enamine library.
Assay data:85 Active, 19958 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
qHTS Assay for Foot and Mouth Disease Virus Antivirals: Primary Screen against the MLPCN compound library
Assay data:1964 Active, 408697 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
qHTS for Suppressors of FUS Proteinopathy: Primary screen using FUS-linked yeast assay
Assay data:932 Active, 388864 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
qHTS assay for MDR1-selective chemotherapeutics: Primary screen using the drug-selected MDR subline cells KB-V1
Assay data:13449 Active, 399619 Tested
qHTS assay for MDR1-selective chemotherapeutics: Primary screen using the parental adenocarcinoma cell KB-3-1
Assay data:5540 Active, 399561 Tested
qHTS for compounds that reverse cellular toxicity of Amyloid beta (A-beta) peptide in yeast: Primary Screen
Assay data:257 Active, 407462 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Inhibitor identification of TROY dependent signaling using uHTS single point assay
Assay data:3555 Active, 360980 Tested
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