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Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 4 (GPX4)
Assay data:258 Active, 16 Activity ≤ 1 µM, 11046 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1)
Assay data:186 Active, 9 Activity ≤ 1 µM, 11353 Tested
Enzymatic assay of human HDAC6 with custom peptide substrate
Assay data:5603 Tested
SummaryRelated BioAssays by Target
Enzymatic assay of human HDAC6 with commercial peptide substrate
Binding affinity to calf thymus DNA assessed as change in melting temperature at DNA to ligand ratio at 40:1 by spectrophotometric method
Assay data:2 Tested
SummaryPubMed Citation
Displacement of EtBr from calf thymus DNA incubated for 3 mins by fluorescence based assay
Assay data:1 Active, 6 Tested
SummaryCompounds, ActivePubMed Citation
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of VERO-6 cells at 10 uM after 48 hours exposure to 0.01 MOI SARS CoV-2 virus by high content imaging
Assay data:7212 Tested
Summary
SARS-CoV-2 3CL-Pro protease inhibition percentage at 20 M by FRET kind of response from peptide substrate
Antiviral activity determined as inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells at 10 uM after 48 hours by high content imaging
Assay data:5612 Tested
Inhibition of glycogen phosphorylase (unknown origin)
Assay data:1 Tested
Inhibition of rabbit muscle glycogen phosphorylase-b after 1 min in presence of varying levels of glucose-1-phosphate and constant concentration of glycogen and AMP by double reciprocal plot method
SummaryPubMed CitationRelated BioAssays by Target
Competitive inhibition of His6-tagged human liver glycogen phosphorylase-a expressed in Escherichia coli BL21 Gold (DE3) assessed as release of inorganic phosphate using varying levels of glucose-1-phosphate and constant concentration of AMP and glycogen measured after 1 min by Dixon plot method
Assay data:2 Active, 2 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Competitive inhibition of rabbit muscle glycogen phosphorylase-a in presence of varying levels of glucose-1-phosphate and constant concentration of glycogen by Hill plot analysis
Assay data:2 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Inhibition of glycogen phosphorylase a (unknown origin)
Assay data:2 Active, 1 Activity ≤ 1 µM, 3 Tested
Inhibition of glycogen phosphorylase b (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 3 Tested
Assay data:1 Active, 55 Tested
SummaryCompounds, Active
Competitive inhibition of rabbit skeletal muscle glycogen phosphorylase b using Glc-1-P as substrate
Assay data:2 Active, 7 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Competitive inhibition of rabbit muscle glycogen phosphorylase b assessed as inorganic phosphate release using alphaD glucose-1-phosphate as substrate at pH 6.8 by spectrophotometric analysis
Assay data:7 Tested
Inhibition of rabbit muscle glycogen phosphorylase inactive form b
Assay data:2 Active, 10 Tested
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