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p53 small molecule agonists, cell-based qHTS assay
Assay data:87 Active, 5 Activity ≤ 1 nM, 180 Activity ≤ 1 µM, 9667 Tested
Summary
Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.
Assay data:1241 Active, 184 Activity ≤ 1 µM, 1545 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Inhibition of SARS-CoV-2-induced cytopathy was measured 4 days after infection of EGFP-labeled Green monkey Vero cells by fluorescence imaging.
Assay data:19 Active, 7 Activity ≤ 1 µM, 134 Tested
Immunosuppressive activity in human B cell
Assay data:8 Active, 4 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Immunosuppressive activity in human T cell
Inhibition of DHFR (unknown origin) incubated for 2 to 5 mins by absorbance based analysis
Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Cytotoxicity against human MDA-MB-231 cells expressing Y1R assessed as reduction in cell viability treated for 8 hrs followed by culturing in proliferation medium for 72 hrs by resazurin assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 7 Tested
Cytotoxicity against human MDA-MB-468 cells expressing Y1R assessed as reduction in cell viability treated for 8 hrs followed by culturing in proliferation medium for 72 hrs by resazurin assay
Assay data:5 Active, 1 Activity ≤ 1 µM, 7 Tested
Inhibition of Toxoplasma gondii DHFR
Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested
TBD from US Patent US11530198: "Compositions and methods for treating infections"
Assay data:6 Active, 2 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Assay data:11 Active, 10 Activity ≤ 1 µM, 11 Tested
Assay data:11 Active, 1 Activity ≤ 1 nM, 11 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
Assay data:50 Active, 50 Activity ≤ 1 µM, 50 Tested
Assay data:58 Active, 25 Activity ≤ 1 µM, 63 Tested
Cytotoxicity against human MDA-MB-231 cells expressing Y1R assessed as reduction in cell viability at 25 uM treated for 8 hrs followed by culturing in proliferation medium for 72 hrs in presence of 10 equiv hY1R agonist, [F7,P34]-NPY by resazurin assay
Assay data:1 Active, 2 Tested
SummaryCompounds, ActivePubMed Citation
Cytotoxicity against human T47D cells expressing Y1R assessed as reduction in cell viability at 5 uM treated for 8 hrs followed by culturing in proliferation medium for 72 hrs in presence of 10 equiv hY1R agonist, [F7,P34]-NPY by resazurin assay
Assay data:1 Active, 1 Tested
Cytotoxicity against human MDA-MB-468 cells expressing Y1R assessed as reduction in cell viability at 10 uM treated for 8 hrs followed by culturing in proliferation medium for 72 hrs in presence of 10 equiv hY1R agonist, [F7,P34]-NPY by resazurin assay
Assay data:1 Active, 4 Tested
Inhibition of Trypanosoma cruzi PTR1 using folic acid as substrate in presence of NADPH by spectrophotometry
Assay data:1 Active, 1 Activity ≤ 1 nM, 1 Activity ≤ 1 µM, 1 Tested
Inhibition of Trypanosoma cruzi DHFR-TS in presence of NADPH by spectrophotometry
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
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