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Binding affinity to human RXRalpha-LBD (224 to 462 residues) expressed in Escherichia coli BL21 (DE3) assessed as dissociation constant using PGC-1alpha as coactivator peptide by isothermal titration calorimetry analysis
Assay data:3 Active, 2 Activity ≤ 1 µM, 3 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at human RXRalpha-LBD (224 to 462 residues) expressed in Escherichia coli BL21 (DE3) assessed as increase in fluorescein labeled D22 coactivator peptide recruitment at 3000 nM incubated for 2 hrs by fluorescence polarization assay
Assay data:3 Active, 4 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Agonist activity at human RXRalpha-LBD (224 to 462 residues) expressed in Escherichia coli BL21 (DE3) assessed as increase in fluorescein labeled PGC-1alpha coactivator peptide recruitment at 3000 nM incubated for 2 hrs by fluorescence polarization assay
Agonist activity at human RXRalpha-LBD (224 to 462 residues) expressed in Escherichia coli BL21 (DE3) assessed as increase in fluorescein labeled SRC1-2 coactivator peptide recruitment at 3000 nM incubated for 2 hrs by fluorescence polarization assay
Binding affinity to human RXRalpha LBD incubated for 2 hrs by fluorescence based assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Displacement of 9-cis-[11,12-3H]-retinoic acid from human RXRalpha LBD incubated for overnight by scintillation counting method
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Agonist activity at human RXRalpha LBD expressed in African green monkey COS1 cells incubated for 24 hrs by luciferase reporter gene assay
Enhancement of 9-cis-[11,12-3H]-retinoic acid binding to human RXRalpha LBD at lower test compound level incubated for overnight by scintillation counting method
Assay data:1 Active, 1 Tested
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