BioAssays, Active for PubChem Compound (Select 134812845) - PubChem BioAssay - NCBI

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Select item 19634981.

HTS to identify compounds that affect the blood-brain barrier permeability in vitro

Source:: Burek Lab, Department of Anaesthesiology, Intensive Care, Emergency and Pain Med, University Hospital Wuerzburg

Assay data:419 Active, 1260 Tested

AID:: 1963498

Summary Compounds, Active

Select item 19142372.

Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000165b PIP5K1C

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914237

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19142363.

Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000165b AAK1

Source:: ChEMBL

Protein Target:: AP2-associated protein kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914236

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19142354.

Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000165b CDKL2

Source:: ChEMBL

Protein Target:: Cyclin-dependent kinase-like 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914235

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19142345.

Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000165b MYLK2

Source:: ChEMBL

Protein Target:: Myosin light chain kinase 2, skeletal/cardiac muscle

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914234

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19142336.

Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000165b RIOK1

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase RIO1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914233

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19142327.

Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000165b RIOK3

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase RIO3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914232

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19132108.

Affinity Biochemical interaction (TR-FRET binding-displacement assays) EUB0000165b BMP2K

Source:: ChEMBL

Protein Target:: BMP-2-inducible protein kinase

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913210

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19132099.

Affinity Biochemical interaction (TR-FRET binding-displacement assays) EUB0000165b AAK1

Source:: ChEMBL

Protein Target:: AP2-associated protein kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913209

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 191295510.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000165b BMP2K

Source:: ChEMBL

Protein Target:: BMP-2-inducible protein kinase

Assay data:1 Active, 1 Tested

AID:: 1912955

Summary Compounds, Active Related BioAssays by Target

Select item 191295411.

Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000165b AAK1

Source:: ChEMBL

Protein Target:: AP2-associated protein kinase 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912954

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 187626712.

Binding affinity to AAK1 (unknown origin) assessed as dissociation constant

Source:: ChEMBL

Protein Target:: AP2-associated protein kinase 1

Assay data:8 Active, 2 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 11 Tested

AID:: 1876267

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 154781213.

Binding affinity to wild type human partial length PIP5K1C (M1 to T668 residues) expressed in mammalian expression system by Kinomescan method

Source:: ChEMBL

Protein Target:: Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1547812

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 154781114.

Binding affinity to wild type human full length RIOK3 (M1 to E519 residues) expressed in bacterial expression system by Kinomescan method

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase RIO3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1547811

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 154781015.

Binding affinity to wild type human full length RIOK1 (M1 to K568 residues) expressed in bacterial expression system by Kinomescan method

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase RIO1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1547810

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 154779816.

Inhibition of tracer K5 binding to N-terminal nano luciferase-fused BMP2K (unknown origin) expressed in HEK293 cells incubated for 2 hrs followed by NanoBRET NanoGlo Substrate addition and measured within 10 mins by NanoBRET assay

Source:: ChEMBL

Protein Target:: BMP-2-inducible protein kinase

Assay data:16 Active, 1 Activity ≤ 1 µM, 16 Tested

AID:: 1547798

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 154779717.

Inhibition of tracer K5 binding to N-terminal nano luciferase-fused AAK1 (unknown origin) expressed in HEK293 cells incubated for 2 hrs followed by NanoBRET NanoGlo Substrate addition and measured within 10 mins by NanoBRET assay

Source:: ChEMBL

Protein Target:: AP2-associated protein kinase 1

Assay data:16 Active, 8 Activity ≤ 1 µM, 16 Tested

AID:: 1547797

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 154779618.

Displacement of Alexafluor labelled kinase tracer236 from biotinylated C-terminal Avi-tagged STK16 kinase domain (13 to 305 residues) (unknown origin) expressed in Escherichia coli measured after 1.5 hrs by TR-FRET assay

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase 16

Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested

AID:: 1547796

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 154779519.

Displacement of Alexafluor labelled kinase tracer236 from biotinylated C-terminal Avi-tagged GAK kinase domain (12 to 347 residues) (unknown origin) expressed in Escherichia coli measured after 1.5 hrs by TR-FRET assay

Source:: ChEMBL

Protein Target:: Cyclin-G-associated kinase

Assay data:18 Active, 5 Activity ≤ 1 µM, 18 Tested

AID:: 1547795

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 154779420.

Displacement of Alexafluor labelled kinase tracer236 from biotinylated C-terminal Avi-tagged BMP2K kinase domain (38 to 345 residues) (unknown origin) expressed in Escherichia coli measured after 1.5 hrs by TR-FRET assay

Source:: ChEMBL

Protein Target:: BMP-2-inducible protein kinase

Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested

AID:: 1547794

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (21)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (19)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (20)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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Literature Extraction (10)
BioAssays extracted from the literature
Other (11)
BioAssays deposited by other experimentalists

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