BioAssays, Active for PubChem Compound (Select 135564980) - PubChem BioAssay - NCBI

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Items: 17

Select item 17984661.

Enzyme Inhibition Assay from Article 10.1021/jm800052b: "A pentacyclic aurora kinase inhibitor (AKI-001) with high in vivo potency and oral bioavailability."

Source:: BindingDB

Protein Targets:: Aurora kinase A; ...
Total:: 2

Assay data:14 Active, 13 Activity ≤ 1 µM, 14 Tested

AID:: 1798466

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 9776082.

Experimentally measured binding affinity data (IC50) for protein-ligand complexes derived from PDB

Source:: Shanghai Institute of Organic Chemistry

Protein Targets:: Chain 1, Chymotrypsinogen A; ...
Total:: 3277

Assay data:4302 Active, 250 Activity ≤ 1 nM, 2931 Activity ≤ 1 µM, 4302 Tested

AID:: 977608

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 3658673.

Inhibition of Src

Source:: ChEMBL

Protein Target:: Proto-oncogene tyrosine-protein kinase Src

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 365867

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 3658664.

Inhibition of KDR

Source:: ChEMBL

Protein Target:: Vascular endothelial growth factor receptor 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 365866

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 3658655.

Inhibition of GSK3-beta

Source:: ChEMBL

Protein Target:: Glycogen synthase kinase-3 beta

Assay data:1 Active, 1 Tested

AID:: 365865

Summary Compounds, Active PubMed Citation Related BioAssays by Target

Select item 3658646.

Inhibition of Flt3

Source:: ChEMBL

Protein Target:: Receptor-type tyrosine-protein kinase FLT3

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 365864

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 3658537.

Inhibition of Aurora B assessed as loss of phospho histone H3 in human HCT cells

Source:: ChEMBL

Protein Target:: Aurora kinase B

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 365853

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 3658528.

Inhibition of Aurora B assessed as loss of phospho histone H3 in human H29 cells

Source:: ChEMBL

Protein Target:: Aurora kinase B

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 365852

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 3658519.

Inhibition of Aurora A assessed as separation of centrosomes in human HCT cells

Source:: ChEMBL

Protein Target:: Aurora kinase A

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 365851

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 36585010.

Inhibition of Aurora A in human HCT cells assessed as loss of autophosphorylation of Aurora A

Source:: ChEMBL

Protein Target:: Aurora kinase A

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 365850

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 36584911.

Cell cycle arrested in human MOLT4 cells assessed as accumulation at G2/M phase after 24 hrs

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 365849

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 36584812.

Antiproliferative activity against human HCT116 cells

Source:: ChEMBL

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 365848

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 36584713.

Antiproliferative activity against human MCF7 cells

Source:: ChEMBL

Assay data:6 Active, 4 Activity ≤ 1 µM, 8 Tested

AID:: 365847

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 36584614.

Antiproliferative activity against human HT29 cells

Source:: ChEMBL

Assay data:5 Active, 3 Activity ≤ 1 µM, 8 Tested

AID:: 365846

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 36584315.

Inhibition of Aurora B

Source:: ChEMBL

Protein Target:: Aurora kinase B

Assay data:10 Active, 10 Activity ≤ 1 µM, 10 Tested

AID:: 365843

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 36584216.

Inhibition of Aurora A

Source:: ChEMBL

Protein Target:: Aurora kinase A

Assay data:14 Active, 12 Activity ≤ 1 µM, 14 Tested

AID:: 365842

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 36584017.

Inhibition of Chk1

Source:: ChEMBL

Protein Target:: Serine/threonine-protein kinase Chk1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 365840

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

Proteins (1)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (17)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (1)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (16)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (16)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (17)
BioAssays extracted from the literature

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