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Inhibition of FABP4 (unknown origin)
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Cmax in ICR mouse at 10 mg/kg, po measured upto 24 hrs by LC-MS/MS analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Displacement of 1,8-ANS from recombinant human 6His-tagged FABP5 expressed in Escherichia coli BL21 DE3 incubated for 15 mins followed by 1,8-ANS addition and measured after 3 mins by fluorescence based assay
Assay data:10 Active, 6 Activity ≤ 1 µM, 12 Tested
Displacement of 1,8-ANS from recombinant human 6His-tagged FABP3 expressed in Escherichia coli BL21 DE3 incubated for 15 mins followed by 1,8-ANS addition and measured after 3 mins by fluorescence based assay
Assay data:10 Active, 4 Activity ≤ 1 µM, 12 Tested
Binding affinity at recombinant human 6His-tagged FABP4 expressed in Escherichia coli BL21 DE3 by isothermal titration calorimetry
Assay data:11 Active, 11 Activity ≤ 1 µM, 11 Tested
Reduction in LPS-induced spleen damage in C57BL/6J mouse at 10 to 50 mg/kg, ig administered for 4 days and measured by H and E staining-based microscopy analysis
Reduction in LPS-induced kidney damage in C57BL/6J mouse at 10 to 50 mg/kg, ig administered for 4 days and measured by H and E staining-based microscopy analysis
Reduction in LPS-induced liver damage in C57BL/6J mouse at 10 to 50 mg/kg, ig administered for 4 days and measured by H and E staining-based microscopy analysis
Reduction in LPS-induced lung damage in C57BL/6J mouse at 10 to 50 mg/kg, ig administered for 4 days and measured by H and E staining-based microscopy analysis
Antiinflammatory activity in C57BL/6J mouse assessed as reduction in LPS-induced IL6 secretion at 50 mg/kg, ig administered 1 hr before LPS stimulation and measured after 5 hrs by ELISA
Assay data:2 Active, 2 Tested
Antiinflammatory activity in C57BL/6J mouse assessed as reduction in LPS-induced MCP1 secretion at 50 mg/kg, ig administered 1 hr before LPS stimulation and measured after 5 hrs by ELISA
Inhibition of FABP4 in mouse 3T3L1 cells assessed as inhibition of forskolin-stimulated lipolysis by measuring free glycerol at 1 to 25 uM incubated for 24 hrs followed by forskolin stimulation and measured after 2 hrs
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Antiinflammatory activity in human THP1 cells assessed as reduction in LPS-induced IL6 secretion at 20 uM incubated for 18 hrs followed by LPS stimulation and measured after 6 hrs by ELISA
Assay data:7 Active, 7 Tested
Antiinflammatory activity in human THP1 cells assessed as reduction in LPS-induced MCP1 secretion at 20 uM incubated for 18 hrs followed by LPS stimulation and measured after 6 hrs by ELISA
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