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Binding affinity to human wild type LY6K assessed as dissociation constant measured upto 250 sec by SPR assay
Assay data:2 Active, 1 Activity ≤ 1 µM, 2 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiproliferative activity against human OVCAR-8 cells after 24 hrs by Cell Titer Blue assay
Assay data:1 Active, 1 Tested
SummaryCompounds, Active
Antiproliferative activity against human BT-549 cells after 24 hrs by Cell Titer Blue assay
Antiproliferative activity against human Hs-578T cells after 24 hrs by Cell Titer Blue assay
Antiproliferative activity against human MDA-MB-231 cells after 24 hrs by Cell Titer Blue assay
Effect on total Ly6K levels in mouse 4T1 cells at 0.1 to 5 mM measured by Western blotting analysis
Induction of autophagy in mouse 4T1 cells at 0.1 to 5 uM assessed as activation of LC3B measured after 16 hrs by Western blot analysis
Down regulation of RhoA in mouse 4T1 cells at 0.1 to 5 uM measured after 16 hrs by Western blot analysis
Induction of apoptosis in mouse 4T1 cells at 0.1 to 5 uM assessed as activation of caspase-7 measured after 16 hrs by Western blot analysis
Induction of apoptosis in mouse 4T1 cells at 0.1 to 5 uM assessed as activation of caspase-3 measured after 16 hrs by Western blot analysis
Induction of apoptosis in mouse 4T1 cells at 0.1 to 5 uM assessed as increase in PARP cleavage measured after 16 hrs by Western blot analysis
Antitumor activity against mouse 4T1 cells xenografted mouse assessed as decrease in Cd11b and Gr-1-dual positive lymphocytes in peripheral blood at 50 mg/kg, iv
Inhibition of IFN-gamma-induced Stat1 phopshorylation in human MDA-MB-231 cells at 2 uM measured after 30 mins by Western blot analysis
Assay data:1 Active, 2 Tested
SummaryCompounds, ActiveRelated BioAssays by Target
Inhibition of TGF-beta1-induced Smad2/3 phopshorylation in human MDA-MB-231 cells at 2 uM measured after 30 mins by Western blot analysis
Down-regulation of PD-L1 expression in human MDA-MB-231 cells at 2 uM measured after 30 mins by Western blot analysis
Antitumor immunity in C57BL/6 mouse xenografted with mouse EO771 cells assessed as reduction in tumor growth at 10 mg/kg, ip administered every 3rd day
Antitumor activity against mouse 4T1 cells allografted in syngenetic BALB/c mouse assessed as tumor growth inhibition at 5 mg/kg, IT(Intratumoral) measured at day 3
Antiproliferative activity against human MDA-MB-231 cells at 2 uM assessed as induction of cells death and measured after 24 hrs by Cell Titer Blue assay relative to control
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