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Inhibitor identification of human QSOX1 enzyme: high-throughput screening using HyperBlu(TM) assay
Assay data:979 Active, 1265 Tested
SummaryCompounds, ActiveRelated BioAssays by Depositor
Human GluN2A (Ionotropic glutamate receptors)
Assay data:35 Active, 35 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Human GluN1 (Ionotropic glutamate receptors)
Assay data:17 Active, 17 Tested
Human GluN2C (Ionotropic glutamate receptors)
Human GluN2B (Ionotropic glutamate receptors)
Assay data:34 Active, 34 Tested
Human glycine receptor alpha2 subunit (Glycine receptors)
Assay data:20 Active, 20 Tested
Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB
Assay data:3598 Active, 421 Activity ≤ 1 nM, 2233 Activity ≤ 1 µM, 3598 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Antagonist activity at NMDA receptor in mouse cortical wedge assessed as inhibition of NMDA-induced membrane depolarization by electrophysiological assay
Assay data:2 Active, 5 Tested
SummaryCompounds, ActivePubMed Citation
Displacement of [3H](+)MK-801 from N-methyl D-aspartate receptor in rat cortical membrane
Assay data:2 Active, 1 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Displacement of [3H]glycine from NMDA receptor in rat cortical synaptical membrane
Assay data:8 Active, 3 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activity was determined by inhibition of glutamate stimulated accumulation of cyclic GMP in neonatal rat cerebral slices.
Assay data:3 Active, 4 Tested
Tested for the antagonistic potency for blockade of NMDA-induced depolarizations in rat cortical slices
Assay data:11 Active, 7 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µM
Tested for ability to inhibit NMDA-induced depolarizations in rat cortical slices
Assay data:9 Active, 4 Activity ≤ 1 µM, 12 Tested
Functional antagonistic potency assessed by determination of the apparent dissociation constant for antagonism of the depolarizations induced by NMDA and AMPA in rat cortical slice preparation
Assay data:11 Active, 1 Activity ≤ 1 µM, 39 Tested
Tested for the ability to suppress the spontaneous epileptiform discharge rate in a cortical wedge model
Assay data:1 Active, 3 Tested
SummaryCompounds, Active
Ability to displace [3H]glycine from NMDA receptor in rat corticaln membranes
Assay data:4 Active, 1 Activity ≤ 1 µM, 6 Tested
In vitro inhibition of [3H]glycine at NMDA receptor
Assay data:46 Active, 38 Activity ≤ 1 µM, 53 Tested
Ability of compound to compete with [3H]glycine for the strychnine-insensitive NMDA receptor glycine binding sites on rat cortical and hippocampus
Assay data:8 Active, 6 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Inhibitory concentration of compound for depolarization induced by 5 uM NMDA in mouse cortical wedge preparation
Assay data:1 Active, 1 Tested
Apparent dissociation constant of [3H]glycine from N-methyl-D-aspartate glutamate receptor in rat cortical slice preparation
Assay data:19 Active, 3 Activity ≤ 1 µM, 62 Tested
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