BioAssays, Active for PubChem Compound (Select 1986) - PubChem BioAssay - NCBI

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Select item 19614931.

Inhibition of human carbonic anhydrase 12 assessed as inhibition constant

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 12

Assay data:4 Active, 1 Activity ≤ 1 µM, 7 Tested

AID:: 1961493

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19614922.

Inhibition of human carbonic anhydrase 1 assessed as inhibition constant

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 1

Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested

AID:: 1961492

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19614903.

Inhibition of human carbonic anhydrase 9 assessed as Ki by stopped-flow carbon dioxide hydration assay

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 9

Assay data:13 Active, 8 Activity ≤ 1 µM, 13 Tested

AID:: 1961490

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19614894.

Inhibition of human carbonic anhydrase 2 assessed as Ki by stopped-flow carbon dioxide hydration assay

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 2

Assay data:13 Active, 13 Activity ≤ 1 µM, 13 Tested

AID:: 1961489

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19611425.

Inhibition of human CA2 by UV spectrophotometric analysis

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 2

Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested

AID:: 1961142

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19611416.

Inhibition of human CA1 by UV spectrophotometric analysis

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 1

Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested

AID:: 1961141

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19611297.

Inhibition of human CA12

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 12

Assay data:5 Active, 5 Activity ≤ 1 µM, 5 Tested

AID:: 1961129

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19611288.

Inhibition of human CA9

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 9

Assay data:7 Active, 7 Activity ≤ 1 µM, 7 Tested

AID:: 1961128

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19611279.

Inhibition of human CA2

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 2

Assay data:54 Active, 54 Activity ≤ 1 µM, 54 Tested

AID:: 1961127

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196112610.

Inhibition of human CA1

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 1

Assay data:57 Active, 54 Activity ≤ 1 µM, 57 Tested

AID:: 1961126

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196112511.

Inhibition of human recombinant CA9

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 9

Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested

AID:: 1961125

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196112412.

Inhibition of human recombinant CA4

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 4

Assay data:8 Active, 8 Activity ≤ 1 µM, 8 Tested

AID:: 1961124

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 196112313.

Inhibition of human recombinant CA2

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 2

Assay data:8 Active, 7 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 8 Tested

AID:: 1961123

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194864814.

Inhibition of human recombinant carbonic anhydrase 12 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 12

Assay data:8 Active, 8 Activity ≤ 1 µM, 9 Tested

AID:: 1948648

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194864715.

Inhibition of human recombinant carbonic anhydrase 9 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 9

Assay data:8 Active, 6 Activity ≤ 1 µM, 9 Tested

AID:: 1948647

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194864616.

Inhibition of human recombinant carbonic anhydrase 2 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 2

Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested

AID:: 1948646

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194864517.

Inhibition of human recombinant carbonic anhydrase 1 assessed as inhibition constant preincubated for 15 mins by phenol red dye based stopped flow CO2 hydration assay

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 1

Assay data:9 Active, 9 Activity ≤ 1 µM, 9 Tested

AID:: 1948645

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194297818.

Binding affinity to human CA9 assessed as inhibition constant

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 9

Assay data:19 Active, 6 Activity ≤ 1 µM, 19 Tested

AID:: 1942978

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194297719.

Binding affinity to human CA7 assessed as inhibition constant

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 7

Assay data:19 Active, 5 Activity ≤ 1 nM, 19 Activity ≤ 1 µM, 19 Tested

AID:: 1942977

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 194297620.

Binding affinity to human CA2 assessed as inhibition constant

Source:: ChEMBL

Protein Target:: Carbonic anhydrase 2

Assay data:19 Active, 19 Activity ≤ 1 µM, 19 Tested

AID:: 1942976

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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Target

Proteins (37)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (2,660)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (319)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (2,585)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Summary (1)
BioAssays summarizing information from multiple assays for validated chemical probes or small molecule leads
Confirmatory (2,613)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations
Primary Screening (1)
Primary high-throughput BioAssays where the activity outcome is based on percentage inhibition from a single dose

Assay Project (1)
BioAssays organized into assay projects based on linkage to Summary assays. Click an project below to retrieve the bioassay list for the project. Click 'All Assay Projects' to retrieve all assay projects represented by Summary assays.

Depositor Category

Literature Extraction (2,653)
BioAssays extracted from the literature
NIH MLP (2)
BioAssays deposited by the NIH Molecular Libraries Program
Other (4)
BioAssays deposited by other experimentalists

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