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Inhibition of Hedgehog-signalling dependent purmorphamine induced osteoblast differentiation in mouse C3H 10T1/2 cells assessed as reduction in ALP expression at 0.01 to 100 uM incubated for 96 hrs by CDP-Star luminogenic substrate based assay
Assay data:6 Active, 6 Tested
SummaryCompounds, ActivePubMed Citation
Cytochrome P450 Family 1 Subfamily A Member 2 (CYP1A2) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2934 Active, 132 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Caspase-3/7 induction in HepG2 cells by small molecules, qHTS assay: Summary
Assay data:415 Active, 9667 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Human pregnane X receptor (PXR) small molecule agonists: Summary
Assay data:2076 Active, 9667 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same Project
Human pregnane X receptor (PXR) small molecule agonists, qHTS assay
Assay data:2218 Active, 1 Activity ≤ 1 nM, 106 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Caspase-3/7 induction in HepG2 cells by small molecules, qHTS assay
Assay data:262 Active, 1 Activity ≤ 1 nM, 30 Activity ≤ 1 µM, 9667 Tested
qHTS assay to identify small molecule agonists of the estrogen related receptor (ERR) signaling pathway from Tox21 library: Summary
Assay data:309 Active, 9667 Tested
qHTS assay to identify small molecule agonists of the estrogen related receptor signaling pathway with the pleiotropic PPARgamma coactivator (PGC) from Tox21 10K library: Summary
Assay data:390 Active, 9667 Tested
qHTS assay to identify small molecule agonists of the estrogen receptor beta (ER-beta) signaling pathway: Summary
Assay data:149 Active, 1 Activity ≤ 1 nM, 52 Activity ≤ 1 µM, 9667 Tested
qHTS assay to identify small molecule antagonists of the estrogen receptor alpha (ER-alpha) signaling pathway using the BG1 cell line in the presence of 0.1 nM 17-beta-estradiol: Summary
Assay data:581 Active, 153 Activity ≤ 1 µM, 9667 Tested
qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line in the presence of 0.5 nM R1881: Summary
Assay data:1108 Active, 2 Activity ≤ 1 nM, 246 Activity ≤ 1 µM, 9667 Tested
qHTS assay to identify small molecule antagonists of the androgen receptor (AR) signaling pathway using the MDA cell line in the presence of 0.5 nM R1881
Assay data:1453 Active, 4 Activity ≤ 1 nM, 292 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
qHTS assay to identify small molecule agonists of the hypoxia (HIF-1) signaling pathway: Summary
Assay data:43 Active, 6 Activity ≤ 1 µM, 9667 Tested
qHTS assay to identify small molecule agonists of the constitutive androstane receptor (CAR) signaling pathway: Summary
Assay data:1090 Active, 9667 Tested
A CellTox Green Cytotoxicity Assay to monitor cytotoxicity in HepG2 cells - 32 hour
Assay data:900 Active, 77 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
A CellTox Green Cytotoxicity Assay to monitor cytotoxicity in HepG2 cells - 40 hour
Assay data:1023 Active, 88 Activity ≤ 1 µM, 9667 Tested
qHTS assay to identify small molecule agonists of the estrogen related receptor (ERR) signaling pathway from Tox21 library
Assay data:318 Active, 199 Activity ≤ 1 µM, 9667 Tested
qHTS assay to identify small molecule agonists of the estrogen related receptor signaling pathway with the pleiotropic PPARgamma coactivator (PGC) from Tox21 10K library
Assay data:323 Active, 134 Activity ≤ 1 µM, 9667 Tested
qHTS assay to identify small molecule inhibitors of firefly luciferase
Assay data:866 Active, 28 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
CCRIS carcinogenicity studies
Assay data:1139 Active, 1767 Tested
SummaryCompounds, Active
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