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Cytotoxicity activity against human HepG2 cells assessed by CellTiter-Glo luminescent cell viability assay.
Assay data:1241 Active, 184 Activity ≤ 1 µM, 1545 Tested
Summary
Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists, luciferase reporter gene qHTS assay in human keratinocytes: Summary
Assay data:1038 Active, 9667 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same Project
Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: luciferase reporter gene qHTS assay in human keratinocytes
Assay data:1099 Active, 1 Activity ≤ 1 nM, 143 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
Anticancer activity against human D283 Med cells assessed as reduction in cell viability incubated for 72 hrs
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Anticancer activity against human MED-MEB-8A cells assessed as reduction in cell viability incubated for 72 hrs
Selective Inhibition Assays of Isolated Na,K-ATPase from US Patent US10668094: "Selective inhibitors of Alpha2-containing isoforms of Na,K-ATPase and use thereof for reduction of intraocular pressure"
Assay data:21 Active, 21 Activity ≤ 1 µM, 21 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
DRC analysis by immunofluorescence from Article 10.1128/AAC.00819-20: "Identification of Antiviral Drug Candidates against SARS-CoV-2 from FDA-Approved Drugs."
Assay data:43 Active, 7 Activity ≤ 1 µM, 48 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Na,K-ATPase Inhibition Assay from Article 10.1074/jbc.M114.557629: "Digoxin derivatives with enhanced selectivity for the a2 isoform of Na,K-ATPase: effects on intraocular pressure in rabbits."
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
Confirmatory qHTS for Inhibitors of ATXN expression
Assay data:939 Active, 132 Activity ≤ 1 µM, 2145 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Primary qHTS for Inhibitors of ATXN expression
Assay data:2593 Active, 3 Activity ≤ 1 nM, 2671 Activity ≤ 1 µM, 361713 Tested
Orthosteric inverse agonist activity at recombinant human N-terminal His6-tagged RORgammat ligand binding domain (265 to 518 residues) expressed in Escherichia coli BL21 (DE3) assessed as reduction in coactivator, N-terminal biotinylated SRC-1 box2 peptide recruitment incubated for 60 mins by TR-FRET assay
Assay data:12 Active, 10 Activity ≤ 1 µM, 14 Tested
Cytotoxicity against human HCC70 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human HCC1937 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-231 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Assay data:8 Active, 5 Activity ≤ 1 µM, 10 Tested
Cytotoxicity against human HCC1806 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human SUM185PE cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-453 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human MDA-MB-468 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human CAL-51 cells assessed as reduction in cell viability after 48 hrs by SRB assay
Cytotoxicity against human Hs-578T cells assessed as reduction in cell viability after 48 hrs by SRB assay
Assay data:10 Active, 6 Activity ≤ 1 µM, 10 Tested
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