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Effect on DNA damage repair in Caulobacter vibrioides lacking uvrA expression assessed as decrease in cell survival rate upto 1 ug/ml and measured after 2 days by agar dilution method
Assay data:4 Active, 5 Tested
SummaryCompounds, ActivePubMed Citation
qHTS assay to identify small molecule antagonists of the estrogen related receptor signaling pathway with the pleiotropic PPARgamma coactivator (PGC) from Tox21 10K library
Assay data:993 Active, 1 Activity ≤ 1 nM, 262 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
CCRIS carcinogenicity studies
Assay data:1139 Active, 1767 Tested
SummaryCompounds, Active
GENE-TOX mutagenicity studies
Assay data:1995 Active, 3214 Tested
CCRIS mutagenicity studies
Assay data:4929 Active, 8266 Tested
qHTS assay for small molecule agonists of the antioxidant response element (ARE) signaling pathway
Assay data:583 Active, 1 Activity ≤ 1 nM, 42 Activity ≤ 1 µM, 2810 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Inhibition of APE1 in human HeLa cells assessed as accumulation of genomic AP sites at 275 uM after 24 hrs by aldehyde reactive probe-based assay relative to control
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Suppression of HEM1 gene in Saccharomyces cerevisiae harboring cdc28-as at 0.002% using deletion pool construction by TAG microarray
Suppression of HEM1 gene in Saccharomyces cerevisiae harboring cdc28-as transfected with 2 uM expression vector TEplac195 at 0.015% using multicopy pool construction by TAG microarray
DSSTox (CPDBAS) Carcinogenic Potency Database Summary MultiCellCall Results
Assay data:582 Active, 1152 Tested
DSSTox (CPDBAS) Carcinogenic Potency Database Summary Mouse Bioassay Results
Assay data:445 Active, 1007 Tested
DSSTox (CPDBAS) Carcinogenic Potency Database Salmonella Mutagenicity
Assay data:403 Active, 860 Tested
DSSTox (CPDBAS) Carcinogenic Potency Database Summary SingleCellCall Results
Assay data:806 Active, 1547 Tested
NCI In Vivo Anticancer Drug Screen. Data for tumor model P388 Leukemia (intracerebral) in CD2F1 (CDF1) mice
Assay data:24 Active, 130 Tested
NCI In Vivo Anticancer Drug Screen. Data for tumor model Lymphosarcoma Gardner 6C3HED (intraperitoneal) in C3AKF1 (CHKRF1) mice
Assay data:39 Active, 85 Tested
NCI In Vivo Anticancer Drug Screen. Data for tumor model Lymphosarcoma Gardner 6C3HED (intraperitoneal) in C3H/He mice
Assay data:35 Active, 115 Tested
NCI In Vivo Anticancer Drug Screen. Data for tumor model Friend Virus Leukemia (Solid) (subcutaneous) in B6D2F1 (BDF1) mice
Assay data:54 Active, 337 Tested
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