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Thymidylate Synthase (TS) Assay from Article 10.1021/jm900490a: "Design, synthesis, and X-ray crystal structure of classical and nonclassical 2-amino-4-oxo-5-substituted-6-ethylthieno[2,3-d]pyrimidines as dual thymidylate synthase and dihydrofolate reductase inhibitors and as potential antitumor agents."
Assay data:19 Active, 19 Activity ≤ 1 µM, 19 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Inhibition of Toxoplasma gondii dihydrofolate reductase
Assay data:18 Active, 17 Activity ≤ 1 µM, 18 Tested
Inhibition of human recombinant dihydrofolate reductase
Assay data:17 Active, 13 Activity ≤ 1 µM, 18 Tested
Inhibition of Toxoplasma gondii thymidylate synthase
Assay data:15 Active, 4 Activity ≤ 1 µM, 18 Tested
Inhibition of Escherichia coli thymidylate synthase
Assay data:13 Active, 2 Activity ≤ 1 µM, 18 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Inhibition of human thymidylate synthase
Assay data:16 Active, 9 Activity ≤ 1 µM, 18 Tested
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