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Binding affinity towards human HRH3 in an in vitro assay with cellular components measured by scintillation counting
Assay data:41 Active, 7 Activity ≤ 1 µM, 993 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Compound was evaluated for inhibition of human PDE4D in an in vitro cell free assay measured by scintillation proximity assay
Assay data:109 Active, 1 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 1242 Tested
Compound was evaluated for inhibition of human KCNH2 in an in vitro assay with cellular components measured by membrane filtration, radioactivity method
Assay data:353 Active, 116 Activity ≤ 1 µM, 1804 Tested
Compound was evaluated for inhibition of human EGFR in an in vitro cell free assay measured by Caliper microfluidic capillary electrophoresis, time-resolved fluorescence resonance energy transfer method
Assay data:11 Active, 1 Activity ≤ 1 nM, 5 Activity ≤ 1 µM, 86 Tested
Binding affinity to human GSK-3beta assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assay
Assay data:25 Active, 1 Activity ≤ 1 nM, 15 Activity ≤ 1 µM, 37 Tested
Binding affinity to human CLK1 assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assay
Assay data:36 Active, 11 Activity ≤ 1 nM, 37 Activity ≤ 1 µM, 37 Tested
Binding affinity to human DYRK1A assessed as equilibrium dissociation constant measured upto 240 min by TR-FRET assay
Assay data:33 Active, 12 Activity ≤ 1 nM, 37 Activity ≤ 1 µM, 37 Tested
Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells using DYRKtide peptide as substrate incubated for 110 mins in presence of ATP by non-radioactive ADP-Glo luminescence microplate reader assay
Assay data:34 Active, 31 Activity ≤ 1 µM, 35 Tested
Inhibition of recombinant human DYRK1A expressed in Escherichia coli using DYRKtide peptide as substrate incubated for 110 mins in presence of ATP by non-radioactive ADP-Glo luminescence microplate reader assay
Assay data:35 Active, 32 Activity ≤ 1 µM, 35 Tested
Inhibition of recombinant human CLK1 expressed in Sf9 insect cells using myelin basic protein as substrate incubated for 110 mins in presence of ATP by non-radioactive ADP-Glo luminescence microplate reader assay
Assay data:32 Active, 29 Activity ≤ 1 µM, 35 Tested
Inhibition of recombinant human GSK-3beta expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis
Assay data:24 Active, 8 Activity ≤ 1 µM, 56 Tested
Inhibition of recombinant human DYRK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis
Assay data:24 Active, 11 Activity ≤ 1 µM, 56 Tested
Inhibition of recombinant human DYRK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis
Assay data:28 Active, 13 Activity ≤ 1 µM, 56 Tested
Inhibition of recombinant human DYRK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis
Assay data:37 Active, 20 Activity ≤ 1 µM, 56 Tested
Inhibition of recombinant human DYRK1B expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis
Assay data:46 Active, 33 Activity ≤ 1 µM, 56 Tested
Inhibition of recombinant human DYRK1A expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis
Assay data:48 Active, 37 Activity ≤ 1 µM, 56 Tested
Inhibition of recombinant human CLK4 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis
Assay data:45 Active, 40 Activity ≤ 1 µM, 56 Tested
Inhibition of recombinant human CLK3 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis
Assay data:31 Active, 11 Activity ≤ 1 µM, 56 Tested
Inhibition of recombinant human CLK2 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis
Assay data:46 Active, 1 Activity ≤ 1 nM, 27 Activity ≤ 1 µM, 56 Tested
Inhibition of recombinant human CLK1 expressed in Sf9 insect cells incubated for 60 mins in presence of ATP and [gamma33-P] ATP by radiometric scintillation counter analysis
Assay data:45 Active, 37 Activity ≤ 1 µM, 56 Tested
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