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Cmax in Sprague-Dawley rat at 10 mg/kg, po by LC-MS analysis
Assay data:1 Active, 1 Tested
SummaryCompounds, ActivePubMed Citation
Activation of human Slo G803D/N806K mutant expressed in human AD293 cells measured at 2 secs interval for 120 secs by FluxOR based fluorescence assay
Assay data:7 Active, 12 Tested
Inhibition of overactive bladder activity in spontaneously hypertensive rat assessed as reduction in voiding frequency at 10 mg/kg, po measured after 3 hrs
Activation of rat Slo expressed in Xenopus laevis oocytes assessed as delayed channel closing 10 uM with 100 mV holding potential by patch-clamp electrophysiological method
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
Activation of rat Slo expressed in Xenopus laevis oocytes assessed as shortened channel opening 10 uM with 100 mV holding potential by patch-clamp electrophysiological method
Activation of rat Slo expressed in Xenopus laevis oocytes at 10 uM with 100 mV holding potential by patch-clamp electrophysiological method
Activation of human Slo G803D/N806K mutant expressed in human AD293 cells assessed as increase in initial velocity at 1 uM measured at 2 secs interval for 120 secs by FluxOR based fluorescence assay
Activation of human Slo G803D/N806K mutant expressed in human AD293 cells assessed as increase in initial velocity at 5 uM measured at 2 secs interval for 4 secs by FluxOR based fluorescence assay
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