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Cytochrome P450 family 3 subfamily A member 7 (CYP3A7) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2481 Active, 355 Activity ≤ 1 µM, 5246 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
NCATS Human Liver Microsomal (HLM) Stability Profiling
Assay data:542 Active, 900 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: OPM1_PLB cell viability assay
Assay data:896 Active, 18 Activity ≤ 1 nM, 320 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: OCIMY7_PLB cell viability assay
Assay data:828 Active, 37 Activity ≤ 1 nM, 590 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS34_JCRB cell viability assay
Assay data:581 Active, 20 Activity ≤ 1 nM, 384 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS28PE_JCRB cell viability assay
Assay data:751 Active, 8 Activity ≤ 1 nM, 310 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: MM1R_ATCC cell viability assay
Assay data:822 Active, 12 Activity ≤ 1 nM, 319 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: MM1S_ATCC cell viability assay
Assay data:1053 Active, 13 Activity ≤ 1 nM, 437 Activity ≤ 1 µM, 1911 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: MOLP8_DSMZ cell viability assay
Assay data:496 Active, 19 Activity ≤ 1 nM, 394 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS26_JCRB cell viability assay
Assay data:699 Active, 23 Activity ≤ 1 nM, 366 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS21BM_JCRB cell viability assay
Assay data:650 Active, 358 Activity ≤ 1 nM, 751 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: KMS12BM_JCRB cell viability assay
Assay data:870 Active, 12 Activity ≤ 1 nM, 424 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: Karpas25_ECACC cell viability assay
Assay data:975 Active, 20 Activity ≤ 1 nM, 350 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: INA6_PLB cell viability assay
Assay data:965 Active, 40 Activity ≤ 1 nM, 443 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: Karpas620_DSMZ cell viability assay
Assay data:592 Active, 16 Activity ≤ 1 nM, 284 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: Delta47_JCRB cell viability assay
Assay data:811 Active, 19 Activity ≤ 1 nM, 394 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: FR4_PLB cell viability assay
Assay data:609 Active, 23 Activity ≤ 1 nM, 283 Activity ≤ 1 µM, 1912 Tested
NCATS Parallel Artificial Membrane Permeability Assay (PAMPA) - Blood-Brain Barrier (BBB) Permeability Screen
Assay data:267 Active, 438 Tested
SummaryCompounds, ActivePubMed Citation
Neuroprotective activity against A53T SNCA-induced cytotoxicity in human SH-SY5Y cells assessed as decrease in A53T SNCA induced LDH release at 100 nM by LDH assay
Assay data:1 Active, 1 Tested
Neuroprotective activity against SNCA-induced neurotoxicity in human SH-SY5Y cells transfected with adenovirus expressing A537 SNCA assessed as inhibition of p62 expression at 100 nM measured after 6 hrs by western blot analysis
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