BioAssays, Active for PubChem Compound (Select 49846946) - PubChem BioAssay - NCBI

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Items: 15

Select item 19633661.

Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay from US Patent US20240043404: "APOPTOSIS INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES"

Source:: BindingDB

Protein Targets:: Apoptosis regulator Bcl-2; ...
Total:: 1

Assay data:372 Active, 356 Activity ≤ 1 nM, 372 Activity ≤ 1 µM, 372 Tested

AID:: 1963366

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19144492.

Selectivity interaction (TR-FRET assay) EUB0000263b MCL1

Source:: ChEMBL

Protein Target:: Induced myeloid leukemia cell differentiation protein Mcl-1

Assay data:1 Active, 1 Tested

AID:: 1914449

Summary Compounds, Active Related BioAssays by Target

Select item 19144483.

Selectivity interaction (GPCR panel (PDSP screen)) EUB0000263b TMEM97

Source:: ChEMBL

Protein Target:: Sigma intracellular receptor 2

Assay data:1 Active, 1 Tested

AID:: 1914448

Summary Compounds, Active Related BioAssays by Target

Select item 19144454.

Selectivity interaction (TR-FRET assay) EUB0000263b BCL2L1

Source:: ChEMBL

Protein Target:: Bcl-2-like protein 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1914445

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19132375.

Affinity Biochemical interaction (TR-FRET assay) EUB0000263b BCL2

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1913237

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 19127826.

Affinity Phenotypic Cellular interaction (CellTiter-Glo Luminescent Cell Viability Assay (BCL-2 dependent cell line RS4-11)) EUB0000263b BCL2

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1912782

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18066187.

TBDTR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) Assay from US Patent US11369599: "Melt-extruded solid dispersions containing an apoptosis-inducing agent"

Source:: BindingDB

Protein Targets:: Apoptosis regulator Bcl-2; ...
Total:: 1

Assay data:365 Active, 349 Activity ≤ 1 nM, 365 Activity ≤ 1 µM, 365 Tested

AID:: 1806618

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 18018228.

Time Resolved-Fluorescence Resonance Energy Transfer (TR-FRET) Assay from US Patent US9174982: "Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases"

Source:: BindingDB

Protein Targets:: Apoptosis regulator Bcl-2; ...
Total:: 1

Assay data:346 Active, 331 Activity ≤ 1 nM, 346 Activity ≤ 1 µM, 346 Tested

AID:: 1801822

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 17976449.

TR-FRET (Time-Resolved Fluorescence-Resonance-Energy-Transfer) assay from US Patent US10213433: "Solid dispersions containing an apoptosis-inducing agent"

Source:: BindingDB

Protein Targets:: Apoptosis regulator Bcl-2; ...
Total:: 1

Assay data:370 Active, 354 Activity ≤ 1 nM, 370 Activity ≤ 1 µM, 370 Tested

AID:: 1797644

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179197610.

CellTiter-Glo Luminescent Cell Viability Assay with RS4-11 cells (BCL-2 dependent cell line)

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested

AID:: 1791976

Summary Compounds, Active Compounds, activity ≤ 1 µM

Select item 179197211.

Time-resolved fluorescence energy transfer (TR-FRET) with BCL2

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:1 Active, 3 Activity ≤ 1 µM, 4 Tested

AID:: 1791972

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Target

Select item 179412712.

KinomeScan assay: inhibition of HIPK4

Source:: ChEMBL

Protein Target:: Homeodomain-interacting protein kinase 4

Assay data:1 Active, 108 Tested

AID:: 1794127

Summary Compounds, Active Related BioAssays by Target

Select item 138844013.

Antiproliferative activity against human RS4:11 cells in presence of 10% human serum

Source:: ChEMBL

Assay data:4 Active, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1388440

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 138843914.

Inhibition of Bcl-xL (unknown origin)

Source:: ChEMBL

Protein Target:: Bcl-2-like protein 1

Assay data:4 Active, 2 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1388439

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 138843815.

Inhibition of Bcl2 (unknown origin)

Source:: ChEMBL

Protein Target:: Apoptosis regulator Bcl-2

Assay data:4 Active, 4 Activity ≤ 1 nM, 4 Activity ≤ 1 µM, 4 Tested

AID:: 1388438

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

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BioActivity

Active Compounds (15)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (6)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (12)
BioAssays with the active concentration of tested reagents less than 1 micromolar

Experiment Type

Confirmatory (14)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

Depositor Category

Literature Extraction (7)
BioAssays extracted from the literature
Other (8)
BioAssays deposited by other experimentalists

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BioAssays, Active for PubChem Compound (Select 49846946) (15)
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