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p53 small molecule agonists, cell-based qHTS assay: Summary
Assay data:212 Active, 41 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
p53 small molecule agonists, cell-based qHTS assay
Assay data:87 Active, 5 Activity ≤ 1 nM, 180 Activity ≤ 1 µM, 9667 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: Karpas25_ECACC cell viability assay
Assay data:975 Active, 20 Activity ≤ 1 nM, 350 Activity ≤ 1 µM, 1912 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Depositor
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: JIM1_ECACC cell viability assay
Assay data:457 Active, 27 Activity ≤ 1 nM, 619 Activity ≤ 1 µM, 1912 Tested
Quantitative High-Throughput drug screen in 47 multiple myeloma cell lines against the NCATS MIPE library collection: ARD_JJKsccE7 cell viability assay
Assay data:643 Active, 44 Activity ≤ 1 nM, 452 Activity ≤ 1 µM, 1912 Tested
Cytotoxicity against human U-87 MG cells measured after 3 days by Celltiter-glo assay
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Antiviral activity against HCV by replicon assay
Assay data:3 Active, 2 Activity ≤ 1 µM, 14 Tested
Confirmatory qHTS for Inhibitors of ATXN expression
Assay data:939 Active, 132 Activity ≤ 1 µM, 2145 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
CMV-Luciferase Counterscreen for Inhibitors of ATXN expression
Assay data:671 Active, 1 Activity ≤ 1 nM, 138 Activity ≤ 1 µM, 2145 Tested
Cytotoxicity against human HDF cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
Assay data:29 Active, 34 Tested
SummaryCompounds, ActivePubMed Citation
Antiproliferative activity against human A549 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
Assay data:31 Active, 6 Activity ≤ 1 µM, 34 Tested
Antiproliferative activity against human U-87 MG cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
Antiproliferative activity against human PC-3 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
Assay data:33 Active, 8 Activity ≤ 1 µM, 35 Tested
Antiproliferative activity against human SK-OV-3 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
Assay data:32 Active, 8 Activity ≤ 1 µM, 35 Tested
Antiproliferative activity against human SK-BR-3 cells assessed as reduction in cell growth incubated for 72 hrs by SRB assay
Antitumor activity against human MV4-11 cells xenografted in female nude mouse assessed as tumor weight growth inhibition at 100 mg/kg, ip measured after 21 days
Assay data:1 Active, 1 Tested
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)
Assay data:2970 Active, 9 Activity ≤ 1 nM, 1016 Activity ≤ 1 µM, 10037 Tested
Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)
Assay data:2826 Active, 4 Activity ≤ 1 nM, 946 Activity ≤ 1 µM, 10037 Tested
VSVG counterscreen qHTS to identify inhibitors of SARS-CoV-2 cell entry
Assay data:280 Active, 114 Activity ≤ 1 µM, 368 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Confirmatory qHTS to identify inhibitors of SARS-CoV-2 cell entry
Assay data:269 Active, 124 Activity ≤ 1 µM, 368 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Depositor
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