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Compound was evaluated for inhibition of human PDE4D in an in vitro cell free assay measured by scintillation proximity assay
Assay data:109 Active, 1 Activity ≤ 1 nM, 13 Activity ≤ 1 µM, 1242 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Antagonist activity at human NR13 in an in vitro cell free assay measured by time-resolved fluorescence resonance energy transfer method
Assay data:13 Active, 3 Activity ≤ 1 µM, 36 Tested
Antagonist activity at human NR1H4 in an in vitro cell free assay measured by luminescence method
Assay data:6 Active, 1 Activity ≤ 1 µM, 36 Tested
Antagonist activity at human HTR2A in an in vitro cell-based assay measured by fluorescent imaging plate reader
Assay data:116 Active, 1 Activity ≤ 1 nM, 39 Activity ≤ 1 µM, 1135 Tested
Compound was evaluated for inhibition of human ABCB11 in an in vitro assay with cellular components measured by filtration, liquid scintillation counting
Assay data:43 Active, 3 Activity ≤ 1 µM, 508 Tested
Cytochrome P450 family 3 subfamily A member 4 (CYP3A4) small molecule antagonists: luciferase cell-based qHTS assay
Assay data:2147 Active, 1 Activity ≤ 1 nM, 377 Activity ≤ 1 µM, 5242 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Rescue cell viability in cybrid cells with a genetic mutation in complex 1 of the mitochondria
Assay data:128 Active, 5056 Tested
SummaryCompounds, ActivePubMed Citation
Antidiabetic activity in glucose-treated rat INS1(832/13) cells assessed as increase in insulin release in presence of 3 mM glucose measured after 2 hrs by radioimmunoassay
Assay data:5 Active, 4 Activity ≤ 1 µM, 5 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Cell-based high throughput primary assay to identify activators of GPR151
Assay data:6756 Active, 646675 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Target
Drug concentration at steady state in human at 0.5 to 4 mg, po BID/TID/QID after 6 hrs
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells
Assay data:1335 Active, 4426 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Depositor
Human ATP-binding cassette, sub-family C (CFTR/MRP), member 8 (ABCC subfamily)
Assay data:2 Active, 2 Tested
SummaryCompounds, ActivePubMed CitationRelated BioAssays by Target
BK Channel Variant Modulator Selectivity Assay
Assay data:286 Active, 904 Activity ≤ 1 nM, 951 Activity ≤ 1 µM, 951 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Cmax in healthy white human with SLCO1B1 521CC/CYP2C8*3/*3 combined genotype at 2 mg, po
Cmax in healthy white human with SLCO1B1 521TC/CYP2C8*3/*3 combined genotype at 2 mg, po
Cmax in healthy white human with CYP2C8*3/*3 genotype at 2 mg, po
Cmax in healthy white human with CYP2C8*1/*3 genotype at 2 mg, po
Cmax in healthy white human with CYP2C8*1/*1 genotype at 2 mg, po
Cmax in healthy white human at 2 mg, po
Cmax in healthy white human with SLCO1B1 521TT/CYP2C8*3/*3 combined genotype at 2 mg, po
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