BioAssays, Active for PubChem Compound (Select 66599893) - PubChem BioAssay - NCBI

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Items: 16

Select item 19392761.

Inhibition of Rock2 (unknown origin) assessed as inhibition constant

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1939276

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19392752.

Induction of disruption of actin stress fibers in human TM1 cells by actin stress fiber assay

Source:: ChEMBL

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1939275

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19392743.

Induction of disruption of actin stress fibers in PTM cells by actin stress fiber assay

Source:: ChEMBL

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1939274

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation

Select item 19392734.

Inhibition of Rock2 (unknown origin) by Kinase Glo luminescence assay

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1939273

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 19392725.

Inhibition of Rock1 (unknown origin) by Kinase Glo luminescence assay

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 1

Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1939272

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 18069616.

ROCK-II(h) In Vitro Inhibition Activity from US Patent US11485707: "Deuterated compounds as rock inhibitors"

Source:: BindingDB

Protein Targets:: Rho-associated protein kinase 2; ...
Total:: 1

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1806961

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 18069607.

ROCK-I(h) In Vitro Inhibition Activity-Method A from US Patent US11485707: "Deuterated compounds as rock inhibitors"

Source:: BindingDB

Protein Targets:: Rho-associated protein kinase 1; ...
Total:: 1

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1806960

Summary Compounds, Active Compounds, activity ≤ 1 µM Related BioAssays by Depositor Related BioAssays by Target

Select item 16741738.

Inhibition of human ROCK2 by Kinase-Glo luminescent assay

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested

AID:: 1674173

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 16458779.

Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an RCH-ACV wild type WT cells (2C)

Source:: National Center for Advancing Translational Sciences (NCATS)

Protein Target:: Histone-lysine N-methyltransferase NSD2

Assay data:2970 Active, 9 Activity ≤ 1 nM, 1016 Activity ≤ 1 µM, 10037 Tested

AID:: 1645877

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 164587610.

Primary qHTS for inhibitors of nuclear receptor binding SET domain protein 2 (NSD2) in an isogenic RCH-ACV NSD2 p.E1099K mutant (9B)

Source:: National Center for Advancing Translational Sciences (NCATS)

Protein Target:: Histone-lysine N-methyltransferase NSD2

Assay data:2826 Active, 4 Activity ≤ 1 nM, 946 Activity ≤ 1 µM, 10037 Tested

AID:: 1645876

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Depositor Related BioAssays by Target

Select item 156412111.

Inhibition of human ROCK1 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate incubated for 20 mins in presence of [gamma33P]ATP by filter binding method

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 1

Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1564121

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 156412012.

Inhibition of human ROCK2 using KEAKEKRQEQIAKRRRLSSLRASTSKSGGSQK as substrate incubated for 20 mins in presence of [gamma33P]ATP by filter binding method

Source:: ChEMBL

Protein Target:: Rho-associated protein kinase 2

Assay data:2 Active, 1 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested

AID:: 1564120

Summary Compounds, Active Compounds, activity ≤ 1 µM PubMed Citation Related BioAssays by Target

Select item 134706513.

Diffuse intrinsic pontine glioma (SU-DIPG-XXV) cell line screen of MIPE5.0 library: viability qHTS assay using CellTiter-Glo

Source:: NIH/NCATS RNAi

Assay data:988 Active, 2480 Tested

AID:: 1347065

Summary Compounds, Active Related BioAssays by Depositor

Select item 134706414.

Diffuse intrinsic pontine glioma (SU-DIPG-XIII) cell line screen of MIPE5.0 library: viability qHTS assay using CellTiter-Glo

Source:: NIH/NCATS RNAi

Assay data:702 Active, 2480 Tested

AID:: 1347064

Summary Compounds, Active Related BioAssays by Depositor

Select item 134706015.

Diffuse intrinsic pontine glioma (SU-DIPG-XVII) cell line screen of MIPE5.0 library: viability qHTS assay using CellTiter-Glo

Source:: NIH/NCATS RNAi

Assay data:889 Active, 2480 Tested

AID:: 1347060

Summary Compounds, Active Related BioAssays by Depositor

Select item 134532716.

Human Rho associated coiled-coil containing protein kinase 2 (Rho kinase)

Source:: IUPHAR/BPS Guide to PHARMACOLOGY

Protein Target:: rho-associated protein kinase 2 isoform 1

Assay data:14 Active, 14 Tested

AID:: 1345327

Summary Compounds, Active PubMed Citation Related BioAssays by Target

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Target

Proteins (3)
BioAssays with protein sequences specified as targets

BioActivity

Active Compounds (16)
BioAssays with compounds reported as biologically active
Activity (IC50, etc) ≤ 1 nM (5)
BioAssays with the active concentration of tested reagents less than 1 nanomolar
Activity (IC50, etc) ≤ 1 µM (12)
BioAssays with the active concentration of tested reagents less than 1 micromolar

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Confirmatory (15)
Low-throughput BioAssays where the activity outcome is based on a dose-response relationship with multiple tested concentrations

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Literature Extraction (11)
BioAssays extracted from the literature
NIH MLP (2)
BioAssays deposited by the NIH Molecular Libraries Program
Other (3)
BioAssays deposited by other experimentalists

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