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Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: qHTS cell viability counter screen in human keratinocytes
Assay data:683 Active, 47 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
Cytochrome P450 Family 3 Subfamily A Member 4 (CYP3A4) small molecule antagonists: luciferase reporter qHTS assay
Assay data:1792 Active, 248 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
Human Ether-a-go-go-Related Gene (hERG) channel small molecule antagonists: fluorescence cell-based qHTS assay
Assay data:704 Active, 81 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Cytochrome P450 Family 2 Subfamily C Member 9 (CYP2C9) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2931 Active, 3 Activity ≤ 1 nM, 133 Activity ≤ 1 µM, 9667 Tested
Cytochrome P450 Family 2 Subfamily C Member 19 (CYP2C19) small molecule antagonists: luciferase reporter qHTS assay
Assay data:3508 Active, 4 Activity ≤ 1 nM, 319 Activity ≤ 1 µM, 9667 Tested
Antagonist activity at ERbeta (unknown origin) expressed in human HeLa cells assessed as inhibition of E2-induced transcriptional activity measured after 24 hrs by luciferase reporter gene assay based Schild plot analysis
Assay data:4 Active, 4 Activity ≤ 1 µM, 6 Tested
Agonist activity at ERalpha (unknown origin) expressed in human HeLa cells assessed as transcriptional activation measured after 24 hrs by luciferase reporter gene assay
Assay data:6 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 7 Tested
Displacement of [3H]17-beta estradiol from GST-fused human recombinant ERbeta ligand binding domain expressed in Escherichia coli BL21alpha cells incubated for 1 hr by liquid scintillation counting method
Assay data:7 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 7 Tested
Displacement of [3H]17-beta estradiol from GST-fused human recombinant ERalpha ligand binding domain expressed in Escherichia coli BL21alpha cells incubated for 1 hr by liquid scintillation counting method
Thyrotropin-releasing hormone receptor (TRHR) small molecule antagonists: Summary
Assay data:130 Active, 9667 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Human pregnane X receptor (PXR) small molecule agonists: Summary
Assay data:2076 Active, 9667 Tested
SummaryCompounds, ActiveRelated BioAssays by DepositorRelated BioAssays by Same Project
TGF-beta/Smad small molecule antagonists, qHTS assay: Summary
Assay data:542 Active, 9667 Tested
Progesterone receptor (PR) small molecule antagonists, qHTS assay: Summary
Assay data:1059 Active, 9667 Tested
Thyrotropin-releasing hormone receptor (TRHR) small molecule agonists: Summary
Assay data:94 Active, 9667 Tested
Human pregnane X receptor (PXR) small molecule agonists, qHTS assay
Assay data:2218 Active, 1 Activity ≤ 1 nM, 106 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Caspase-3/7 induction in CHO-K1 cells by small molecules, qHTS cell viability counter screen
Assay data:1380 Active, 82 Activity ≤ 1 µM, 9667 Tested
qHTS assay to identify small molecule antagonists of the progesterone receptor (PR) signaling pathway
Assay data:724 Active, 1 Activity ≤ 1 nM, 121 Activity ≤ 1 µM, 9667 Tested
qHTS assay to identify small molecule antagonists of the estrogen receptor beta (ER-beta) signaling pathway: Summary
Assay data:593 Active, 9667 Tested
qHTS assay to identify small molecule antagonists of the sonic hedgehog signaling (Shh) pathway: Summary
Assay data:1156 Active, 2 Activity ≤ 1 nM, 322 Activity ≤ 1 µM, 9667 Tested
qHTS assay to identify small molecule agonists of the estrogen receptor alpha (ER-alpha) signaling pathway in the presence of an antagonist: Summary
Assay data:219 Active, 9667 Tested
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