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Nuclear factor erythroid 2-related factor 2/antioxidant responsive element (Nrf2/ARE) small molecule agonists: luciferase reporter gene qHTS assay in human keratinocytes
Assay data:1099 Active, 1 Activity ≤ 1 nM, 143 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
Agonist activity at human PPARdelta expressed in HEK293 cells by luciferase/beta-galactosidase reporter gene assay
Assay data:3 Active, 1 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Agonist activity at pBIND tagged human PPARdelta expressed in human HepG2 cells incubated for 18 hrs by dual luciferase reporter assay
Assay data:24 Active, 9 Activity ≤ 1 µM, 27 Tested
Agonist activity at human PPARdelta measured by dual luciferase reporter gene assay
Assay data:11 Active, 1 Activity ≤ 1 µM, 17 Tested
In vivo agonist activity at human GFP-tagged PPARalpha in transgenic zebrafish assessed as increase in GFP expression in muscle at 1.5 uM measured after 14 days by microscopy
Assay data:2 Active, 3 Tested
SummaryCompounds, ActivePubMed Citation
In vivo agonist activity at human GFP-tagged PPARalpha in transgenic zebrafish assessed as increase in GFP expression in heart at 1.5 uM measured after 14 days by microscopy
In vivo agonist activity at human GFP-tagged PPARalpha in transgenic zebrafish assessed as increase in GFP expression in yolk sac at 1.5 uM measured after 14 days by microscopy
In vivo agonist activity at human GFP-tagged PPARalpha in transgenic zebrafish assessed as increase in GFP expression in brain at 1.5 uM measured after 14 days by microscopy
In vivo agonist activity at human GFP-tagged PPARgamma in transgenic zebrafish assessed as increase in GFP expression in muscle at 1 uM measured after 14 days by microscopy
Assay data:1 Active, 2 Tested
In vivo agonist activity at human GFP-tagged PPARgamma in transgenic zebrafish assessed as increase in GFP expression in CNS at 1 uM measured after 14 days by microscopy
Primary qHTS Assay for Inhibitors of Recombinant Selenoprotein Glutathione Peroxidase 1 (GPX1)
Assay data:186 Active, 9 Activity ≤ 1 µM, 11353 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Target
Agonist activity at human PPARgamma transfected in COS-7 cells assessed luciferase activity measured after 24 hrs by cell based luciferase transactivation assay
Assay data:4 Active, 1 Activity ≤ 1 µM, 10 Tested
Agonist activity at human PPARdelta transfected in COS-7 cells assessed luciferase activity measured after 24 hrs by cell based luciferase transactivation assay
Assay data:9 Active, 7 Activity ≤ 1 µM, 10 Tested
Agonist activity at human PPARalpha transfected in COS-7 cells assessed luciferase activity measured after 24 hrs by cell based luciferase transactivation assay
Assay data:6 Active, 2 Activity ≤ 1 µM, 10 Tested
Agonist activity at human PPARdelta transfected in human HEK293 cells incubated for 18 hrs by Renilla/Firefly dual-luciferase reporter assay
Assay data:14 Active, 9 Activity ≤ 1 µM, 16 Tested
Antiosteoporotic activity against OVX-induced bone loss C57BL/6 mouse model assessed as increase in trabecular bone density at 10 mg/kg, po for 6 weeks by microcomputed tomography method relative to sham treated control
Assay data:4 Active, 4 Tested
Induction of osteogenesis differentiation in human Mesenchymal stem cells at 10 uM incubated for 21 days by Alizarin Red S staining-based microscopic analysis
Assay data:16 Active, 31 Tested
Induction of osteogenesis differentiation in human Mesenchymal stem cells at 1 uM incubated for 21 days by Alizarin Red S staining-based microscopic analysis
Assay data:27 Active, 31 Tested
Agonist activity at human PPAR-delta
Assay data:1 Active, 1 Activity ≤ 1 µM, 2 Tested
Cytochrome P450 Family 2 Subfamily C Member 9 (CYP2C9) small molecule antagonists: luciferase reporter qHTS assay
Assay data:2931 Active, 3 Activity ≤ 1 nM, 133 Activity ≤ 1 µM, 9667 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
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