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Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000165b PIP5K1C
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000165b AAK1
Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000165b CDKL2
Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000165b MYLK2
Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000165b RIOK1
Selectivity interaction (KinomeScan (DiscoverX, competition-binding assay)) EUB0000165b RIOK3
Affinity Biochemical interaction (TR-FRET binding-displacement assays) EUB0000165b BMP2K
Affinity Biochemical interaction (TR-FRET binding-displacement assays) EUB0000165b AAK1
Affinity On-target Cellular interaction (NanoBRET assay (HEK293T cells)) EUB0000165b AAK1
Binding affinity to AAK1 (unknown origin) assessed as dissociation constant
Assay data:8 Active, 2 Activity ≤ 1 nM, 7 Activity ≤ 1 µM, 11 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Binding affinity to wild type human partial length PIP5K1C (M1 to T668 residues) expressed in mammalian expression system by Kinomescan method
Binding affinity to wild type human full length RIOK3 (M1 to E519 residues) expressed in bacterial expression system by Kinomescan method
Binding affinity to wild type human full length RIOK1 (M1 to K568 residues) expressed in bacterial expression system by Kinomescan method
Inhibition of tracer K5 binding to N-terminal nano luciferase-fused AAK1 (unknown origin) expressed in HEK293 cells incubated for 2 hrs followed by NanoBRET NanoGlo Substrate addition and measured within 10 mins by NanoBRET assay
Assay data:16 Active, 8 Activity ≤ 1 µM, 16 Tested
Displacement of Alexafluor labelled kinase tracer236 from biotinylated C-terminal Avi-tagged STK16 kinase domain (13 to 305 residues) (unknown origin) expressed in Escherichia coli measured after 1.5 hrs by TR-FRET assay
Assay data:18 Active, 18 Activity ≤ 1 µM, 18 Tested
Displacement of Alexafluor labelled kinase tracer236 from biotinylated C-terminal Avi-tagged BMP2K kinase domain (38 to 345 residues) (unknown origin) expressed in Escherichia coli measured after 1.5 hrs by TR-FRET assay
Displacement of Alexafluor labelled kinase tracer236 from biotinylated C-terminal Avi-tagged AAK1 kinase domain (31 to 396 residues) (unknown origin) expressed in Escherichia coli measured after 1.5 hrs by TR-FRET assay
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