Warning: The NCBI web site requires JavaScript to function. more...
An official website of the United States government
The .gov means it's official. Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.
The site is secure. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.
SERT Uptake Inhibition Assay from US Patent US11767305: "Advantageous benzofuran compositions for mental disorders or enhancement"
Assay data:13 Active, 11 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Activity at NET in rat synaptosomes assessed as release of [3H]NE after 30 mins by liquid scintillation counting method
Assay data:10 Active, 10 Activity ≤ 1 µM, 13 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Activity at DAT in rat synaptosomes assessed as release of [3H]DA after 5 mins by liquid scintillation counting method
Assay data:12 Active, 10 Activity ≤ 1 µM, 12 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
Activity at SERT in rat synaptosomes assessed as release of [3H]HT after 5 mins by liquid scintillation counting method
Binding affinity to human NET expressed in HEK293 cells assessed as induction of [3H]MPP+ release by liquid scintillation counting method
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Binding affinity to human DAT expressed in HEK293 cells assessed as induction of [3H]MPP+ release by liquid scintillation counting method
Binding affinity to human SERT expressed in HEK293 cells assessed as induction of [3H]5-HT release by liquid scintillation counting method
Binding affinity to NET in Sprague-Dawley rat brain synaptosomes assessed as induction of [3H]MPP+ release by liquid scintillation counting method
Assay data:6 Active, 5 Activity ≤ 1 µM, 6 Tested
Binding affinity to DAT in Sprague-Dawley rat brain synaptosomes assessed as induction of [3H]MPP+ release by liquid scintillation counting method
Assay data:5 Active, 5 Activity ≤ 1 µM, 6 Tested
Binding affinity to SERT in Sprague-Dawley rat brain synaptosomes assessed as induction of [3H]5-HT release by liquid scintillation counting method
Assay data:6 Active, 6 Activity ≤ 1 µM, 6 Tested
Inhibition of [3H]dopamine uptake at human DAT expressed in HEK293 cells preincubated for 10 mins prior to substrate addition measured after 4 mins by FLIPR assay
Assay data:9 Active, 5 Activity ≤ 1 µM, 10 Tested
Inhibition of [3H]norepinephrine uptake at human NET expressed in HEK293 cells preincubated for 10 mins prior to substrate addition measured after 4 mins by FLIPR assay
Assay data:9 Active, 6 Activity ≤ 1 µM, 10 Tested
Inhibition of [3H]5-HT uptake at human SERT expressed in HEK293 cells preincubated for 10 mins prior to substrate addition measured after 4 mins by FLIPR assay
Assay data:10 Active, 6 Activity ≤ 1 µM, 10 Tested
Binding affinity to human NET
Assay data:2 Active, 2 Activity ≤ 1 µM, 2 Tested
Binding affinity to human SERT
Inhibition of human noradrenaline transporter
Assay data:4 Active, 3 Activity ≤ 1 µM, 4 Tested
Inhibition of [3H]5-HT uptake at SERT
Displacement of [3H]paroxetine from human SERT expressed in HEK293 cells
Assay data:9 Active, 1 Activity ≤ 1 nM, 6 Activity ≤ 1 µM, 9 Tested
Displacement of [3H]citalopram from human SERT expressed in HEK293 cells
Assay data:9 Active, 2 Activity ≤ 1 nM, 8 Activity ≤ 1 µM, 9 Tested
Binding affinity was determined towards serotonin uptake site in presence of [3H]paroxetine radioligand in rat hippocampal homogenate
Assay data:2 Active, 2 Activity ≤ 1 nM, 2 Activity ≤ 1 µM, 2 Tested
Filters: Manage Filters
Your browsing activity is empty.
Activity recording is turned off.
Turn recording back on