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Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB
Assay data:3598 Active, 421 Activity ≤ 1 nM, 2233 Activity ≤ 1 µM, 3598 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Target
qHTS screen for enhancers of Arylsulfatase A (ASA1): LOPAC Validation Assay
Assay data:33 Active, 179 Activity ≤ 1 µM, 1277 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by DepositorRelated BioAssays by Same ProjectRelated BioAssays by Target
Displacement of [3H](+)MK-801 from N-methyl D-aspartate receptor in rat cortical membrane
Assay data:2 Active, 1 Activity ≤ 1 µM, 6 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed Citation
Displacement of [3H]glycine from NMDA receptor in rat cortical synaptical membrane
Assay data:8 Active, 3 Activity ≤ 1 µM, 8 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMPubMed CitationRelated BioAssays by Target
qHTS for Inhibitors of binding or entry into cells for Lassa Virus
Assay data:3699 Active, 99 Activity ≤ 1 nM, 6304 Activity ≤ 1 µM, 300904 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by DepositorRelated BioAssays by Same Project
qHTS Assay for Inhibitors of Tyrosyl-DNA Phosphodiesterase (TDP1)
Assay data:986 Active, 18 Activity ≤ 1 nM, 825 Activity ≤ 1 µM, 352260 Tested
Ability to displace [3H]glycine from NMDA receptor in rat corticaln membranes
Assay data:4 Active, 1 Activity ≤ 1 µM, 6 Tested
In vitro inhibition of [3H]glycine at NMDA receptor
Assay data:46 Active, 38 Activity ≤ 1 µM, 53 Tested
Ability of compound to compete with [3H]glycine for the strychnine-insensitive NMDA receptor glycine binding sites on rat cortical and hippocampus
Assay data:8 Active, 6 Activity ≤ 1 µM, 9 Tested
SummaryCompounds, ActiveCompounds, activity ≤ 1 µMRelated BioAssays by Target
Tested for the binding affinity at glycine recognition site of the NMDA receptor in rat cortical membranes using radiolabeled [3H]- L-689 560
Assay data:6 Active, 6 Activity ≤ 1 µM, 7 Tested
Tested for the ability to inhibit [3H]MK-801 binding to NMDA receptor of rat cortical membranes in the presence of glutamate (1 uM)
Assay data:4 Active, 1 Activity ≤ 1 µM, 9 Tested
Inhibition of [3H]glycine binding to glycine site of N-methyl-D-aspartate glutamate receptor in rat cortical membranes
Assay data:30 Active, 12 Activity ≤ 1 µM, 51 Tested
Displacement of [3H]L-689,560 from NMDA receptor glycine site of rat brain membranes
Assay data:12 Active, 9 Activity ≤ 1 µM, 14 Tested
Binding activity against N-methyl-D-aspartate glutamate receptor in rat brain homogenate using [3H]-glycine as the radioligand.
Assay data:4 Active, 3 Activity ≤ 1 µM, 5 Tested
Binding affinity towards N-methyl-D-aspartate glutamate receptor 1 (high affinity) of rat cortical synaptic membranes by using [3H]Gly as radioligand
Assay data:9 Active, 1 Activity ≤ 1 µM, 21 Tested
Ability to compete with [3H]glycine for strychnine-insensitive binding sites on rat cortical and hippocampal membrane
Assay data:10 Active, 3 Activity ≤ 1 µM, 28 Tested
Inhibition of specific binding of [3H]glycine to NMDA receptors, in rat cortical membranes at 32 uM conc.
Assay data:1 Active, 1 Activity ≤ 1 µM, 1 Tested
Affinity for the glycine binding site on rat N-methyl-D-aspartate glutamate receptor 1, determined by displacement of the glycine site antagonist [3H]L-689,560 from rat cortical membranes
Assay data:73 Active, 1 Activity ≤ 1 nM, 60 Activity ≤ 1 µM, 76 Tested
Activity against rat cortical and hippocampal membrane strychnine-insensitive N-methyl-D-aspartate glutamate receptor 1 using [3H]-gly
Assay data:6 Active, 3 Activity ≤ 1 µM, 11 Tested
Functional antagonism at the N-methyl-D-aspartate glutamate receptor 1 was demonstarted by the ability to inhibit the binding of the channel-blocking agent [3H](+)-MK-801
Assay data:8 Active, 1 Activity ≤ 1 µM, 15 Tested
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